Gold nanorods for fluorescence lifetime imaging in biology

Y. Zhang, Jun Yu, David Birch, Yu Chen

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Two-photon luminescence (TPL) from gold nanorods shows considerable potential in biological imaging. We study the imaging of gold nanorods in Madin-Darby canine kidney (MDCK) cells using fluorescence lifetime imaging microscopy (FLIM). FLIM provides images with better contrast and sensitivity than intensity imaging. The characteristic fluorescence lifetime of gold nanorods is found to be less than 100 ps, which can be used to distinguish gold nanorods from other fluorescent labels and endogenous fluorophores in lifetime imaging.
Original languageEnglish
Article number20504
Number of pages3
JournalJournal of Biomedical Optics
Volume15
Issue number2
DOIs
Publication statusPublished - 2 Apr 2010

Keywords

  • two-photon luminescence
  • madin-darby canine kidney cells
  • fluorescence lifetime imaging microscopy
  • gold nanorods

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