Gold nanorods for applications in biological imaging

Y. Zhang, J. Yu, D. J. S. Birch, Y. Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

8 Citations (Scopus)


Two-Photon luminescence (TPL) from gold nanorods shows considerable potential in biological imaging for high resolution, low photo-damage, tunable near infra-red (NIR) longitudinal band, polarization dependence, ability to conjugate to bio-molecules and low toxicity. Here we demonstrate the application of gold nanorods as TPL imaging agents by studying the gold nanorods taken up by Madin-Darby canine kidney (MDCK) cells using both confocal imaging and fluorescence lifetime imaging microscopy (FLIM). The characteristic luminescence lifetime of gold nanorods is found to be less than 100 ps, which can be used to distinguish gold nanorods from other fluorescent labels and endogenous fluorophores in lifetime imaging.
Original languageEnglish
Title of host publicationReporters, markers, dyes, nanoparticles and molecular probes for biomedical applications III
EditorsS. Achilefu, R. Raghavachari
Place of PublicationBellingham
Publication statusPublished - 2011
EventConference on Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III - San Francisco, United States
Duration: 24 Jan 201126 Jan 2011

Publication series

NameProceedings of SPIE
ISSN (Print)0277-786X


ConferenceConference on Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
Country/TerritoryUnited States
CitySan Francisco


  • time
  • surface plasmon
  • contrast agents
  • cells
  • photoluminescence
  • optical-properties
  • nanoparticles
  • gold nanorods
  • metal-enhanced fluroescence
  • luminescence
  • microscopy
  • two-photon luminescence
  • fluorescence lifetime imaging
  • emission
  • biological imaging


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