Glycosylated foldamers to probe the carbohydrate−carbohydrate interaction

Graham L. Simpson, Andrew H Gordon, David M. Lindsay, Netnapa Promsawan, Matthew P. Crump, Keith Mulholland, Barry R. Hayter, Timothy Gallagher

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Abstract

The synthesis of a triglycosylated helical foldamer based on a combination of cyclopentyl- and pyrrolidinyl-based amino acids is described. This structure is stable in water, maintaining as it does a series of carbohydrate units in proximity to one another, and represents the basis of a new approach to the study of carbohydrate−carbohydrate interactions.
Original languageEnglish
Pages (from-to)10638-10639
Number of pages2
JournalJournal of the American Chemical Society
Volume128
Issue number33
DOIs
Publication statusPublished - 1 Aug 2006

Keywords

  • foldamers
  • peptdies and proteins
  • carbohydrates
  • monomers
  • scaffolds

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    Simpson, G. L., Gordon, A. H., Lindsay, D. M., Promsawan, N., Crump, M. P., Mulholland, K., Hayter, B. R., & Gallagher, T. (2006). Glycosylated foldamers to probe the carbohydrate−carbohydrate interaction. Journal of the American Chemical Society , 128(33), 10638-10639. https://doi.org/10.1021/ja0614565