Glycosylated foldamers to probe the carbohydrate−carbohydrate interaction

Graham L. Simpson; Andrew H Gordon; David M. Lindsay; Netnapa Promsawan; Matthew P. Crump; Keith  Mulholland; Barry R. Hayter; Timothy Gallagher

doi:10.1021/ja0614565

Glycosylated foldamers to probe the carbohydrate−carbohydrate interaction

Graham L. Simpson, Andrew H Gordon, David M. Lindsay, Netnapa Promsawan, Matthew P. Crump, Keith Mulholland, Barry R. Hayter, Timothy Gallagher

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

The synthesis of a triglycosylated helical foldamer based on a combination of cyclopentyl- and pyrrolidinyl-based amino acids is described. This structure is stable in water, maintaining as it does a series of carbohydrate units in proximity to one another, and represents the basis of a new approach to the study of carbohydrate−carbohydrate interactions.

Original language	English
Pages (from-to)	10638-10639
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	128
Issue number	33
DOIs	https://doi.org/10.1021/ja0614565
Publication status	Published - 1 Aug 2006

Keywords

foldamers
peptdies and proteins
carbohydrates
monomers
scaffolds

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10.1021/ja0614565

Cite this

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title = "Glycosylated foldamers to probe the carbohydrate−carbohydrate interaction",

abstract = "The synthesis of a triglycosylated helical foldamer based on a combination of cyclopentyl- and pyrrolidinyl-based amino acids is described. This structure is stable in water, maintaining as it does a series of carbohydrate units in proximity to one another, and represents the basis of a new approach to the study of carbohydrate−carbohydrate interactions. ",

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author = "Simpson, {Graham L.} and Gordon, {Andrew H} and Lindsay, {David M.} and Netnapa Promsawan and Crump, {Matthew P.} and Keith Mulholland and Hayter, {Barry R.} and Timothy Gallagher",

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T1 - Glycosylated foldamers to probe the carbohydrate−carbohydrate interaction

AU - Simpson, Graham L.

AU - Gordon, Andrew H

AU - Lindsay, David M.

AU - Promsawan, Netnapa

AU - Crump, Matthew P.

AU - Mulholland, Keith

AU - Hayter, Barry R.

AU - Gallagher, Timothy

PY - 2006/8/1

Y1 - 2006/8/1

N2 - The synthesis of a triglycosylated helical foldamer based on a combination of cyclopentyl- and pyrrolidinyl-based amino acids is described. This structure is stable in water, maintaining as it does a series of carbohydrate units in proximity to one another, and represents the basis of a new approach to the study of carbohydrate−carbohydrate interactions.

AB - The synthesis of a triglycosylated helical foldamer based on a combination of cyclopentyl- and pyrrolidinyl-based amino acids is described. This structure is stable in water, maintaining as it does a series of carbohydrate units in proximity to one another, and represents the basis of a new approach to the study of carbohydrate−carbohydrate interactions.

KW - foldamers

KW - peptdies and proteins

KW - carbohydrates

KW - monomers

KW - scaffolds

U2 - 10.1021/ja0614565

DO - 10.1021/ja0614565

M3 - Article

SN - 0002-7863

VL - 128

SP - 10638

EP - 10639

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 33

ER -

Glycosylated foldamers to probe the carbohydrate−carbohydrate interaction

Abstract

Keywords

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