The synthesis of a triglycosylated helical foldamer based on a combination of cyclopentyl- and pyrrolidinyl-based amino acids is described. This structure is stable in water, maintaining as it does a series of carbohydrate units in proximity to one another, and represents the basis of a new approach to the study of carbohydrate−carbohydrate interactions.
- peptdies and proteins
Simpson, G. L., Gordon, A. H., Lindsay, D. M., Promsawan, N., Crump, M. P., Mulholland, K., Hayter, B. R., & Gallagher, T. (2006). Glycosylated foldamers to probe the carbohydrate−carbohydrate interaction. Journal of the American Chemical Society , 128(33), 10638-10639. https://doi.org/10.1021/ja0614565