Glucose uptake stimulatory effect of akuammicine from picralima nitida (Apocynaceae)

H Shittu; Alexander Gray; Brian Furman; Louise Young

doi:10.1016/j.phytol.2009.11.003

Glucose uptake stimulatory effect of akuammicine from picralima nitida (Apocynaceae)

H Shittu, Alexander Gray, Brian Furman, Louise Young

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

A bioactivity-guided fractionation of the chloroform extract of the seeds of Picralima nitida using glucose uptake in fully differentiated 3T3-L1 adipocytes afforded six indole alkaloids (akuammicine, 10-deoxyakuammine, akuammine, akuammidine, burnamine and picraline) and a mixture of four 5-hydroxy tryptamine amides. Akuammicine accounted for the increase in glucose uptake observed in the chloroform extract. (C) 2009 Phytochemical Society of Europe.

Original language	English
Pages (from-to)	53-55
Number of pages	3
Journal	Phytochemistry Letters
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/j.phytol.2009.11.003
Publication status	Published - 12 Mar 2010

Keywords

glucose uptake
stimulatory effect
akuammicine
picralima nitida
apocynaceae

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10.1016/j.phytol.2009.11.003

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abstract = "A bioactivity-guided fractionation of the chloroform extract of the seeds of Picralima nitida using glucose uptake in fully differentiated 3T3-L1 adipocytes afforded six indole alkaloids (akuammicine, 10-deoxyakuammine, akuammine, akuammidine, burnamine and picraline) and a mixture of four 5-hydroxy tryptamine amides. Akuammicine accounted for the increase in glucose uptake observed in the chloroform extract. (C) 2009 Phytochemical Society of Europe. ",

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AU - Shittu, H

AU - Gray, Alexander

AU - Furman, Brian

AU - Young, Louise

PY - 2010/3/12

Y1 - 2010/3/12

N2 - A bioactivity-guided fractionation of the chloroform extract of the seeds of Picralima nitida using glucose uptake in fully differentiated 3T3-L1 adipocytes afforded six indole alkaloids (akuammicine, 10-deoxyakuammine, akuammine, akuammidine, burnamine and picraline) and a mixture of four 5-hydroxy tryptamine amides. Akuammicine accounted for the increase in glucose uptake observed in the chloroform extract. (C) 2009 Phytochemical Society of Europe.

AB - A bioactivity-guided fractionation of the chloroform extract of the seeds of Picralima nitida using glucose uptake in fully differentiated 3T3-L1 adipocytes afforded six indole alkaloids (akuammicine, 10-deoxyakuammine, akuammine, akuammidine, burnamine and picraline) and a mixture of four 5-hydroxy tryptamine amides. Akuammicine accounted for the increase in glucose uptake observed in the chloroform extract. (C) 2009 Phytochemical Society of Europe.

KW - glucose uptake

KW - stimulatory effect

KW - akuammicine

KW - picralima nitida

KW - apocynaceae

U2 - 10.1016/j.phytol.2009.11.003

DO - 10.1016/j.phytol.2009.11.003

M3 - Article

VL - 3

SP - 53

EP - 55

JO - Phytochemistry Letters

JF - Phytochemistry Letters

IS - 1

ER -

Glucose uptake stimulatory effect of akuammicine from picralima nitida (Apocynaceae)

Abstract

Keywords

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