Glucose uptake stimulatory effect of akuammicine from picralima nitida (Apocynaceae)

H Shittu, Alexander Gray, Brian Furman, Louise Young

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A bioactivity-guided fractionation of the chloroform extract of the seeds of Picralima nitida using glucose uptake in fully differentiated 3T3-L1 adipocytes afforded six indole alkaloids (akuammicine, 10-deoxyakuammine, akuammine, akuammidine, burnamine and picraline) and a mixture of four 5-hydroxy tryptamine amides. Akuammicine accounted for the increase in glucose uptake observed in the chloroform extract. (C) 2009 Phytochemical Society of Europe.
LanguageEnglish
Pages53-55
Number of pages3
JournalPhytochemistry Letters
Volume3
Issue number1
DOIs
Publication statusPublished - 12 Mar 2010

Fingerprint

Apocynaceae
Chloroform
chloroform
Indole Alkaloids
Glucose
glucose
indole alkaloids
seed extracts
Fractionation
amides
Bioactivity
adipocytes
Adipocytes
serotonin
Amides
Seed
Seeds
fractionation
extracts
akuammicine

Keywords

  • glucose uptake
  • stimulatory effect
  • akuammicine
  • picralima nitida
  • apocynaceae

Cite this

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Glucose uptake stimulatory effect of akuammicine from picralima nitida (Apocynaceae). / Shittu, H; Gray, Alexander; Furman, Brian; Young, Louise.

In: Phytochemistry Letters, Vol. 3, No. 1, 12.03.2010, p. 53-55.

Research output: Contribution to journalArticle

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AU - Shittu, H

AU - Gray, Alexander

AU - Furman, Brian

AU - Young, Louise

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AB - A bioactivity-guided fractionation of the chloroform extract of the seeds of Picralima nitida using glucose uptake in fully differentiated 3T3-L1 adipocytes afforded six indole alkaloids (akuammicine, 10-deoxyakuammine, akuammine, akuammidine, burnamine and picraline) and a mixture of four 5-hydroxy tryptamine amides. Akuammicine accounted for the increase in glucose uptake observed in the chloroform extract. (C) 2009 Phytochemical Society of Europe.

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KW - stimulatory effect

KW - akuammicine

KW - picralima nitida

KW - apocynaceae

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