Book chapter explains how glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase.
|Title of host publication||Activation and Desensitisation of Transducing Pathways|
|Editors||T.M. Konijn, M.D. Houslay, P.J.M. van Haastert|
|Number of pages||11|
|Publication status||Published - 1990|
- transducing pathways