Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase

M.D. Houslay, M Bushfield, E Kilgour, B E Lavan, S Griffiths, Nigel Pyne, I Tang, G Murphy

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

Abstract

Book chapter explains how glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase.
Original languageEnglish
Title of host publicationActivation and Desensitisation of Transducing Pathways
EditorsT.M. Konijn, M.D. Houslay, P.J.M. van Haastert
PublisherSpringer-Verlag
Pages63-83
Number of pages11
Volume44
ISBN (Print)9783642836183
Publication statusPublished - 1990

Publication series

NameNATO ASI series

Fingerprint

Phosphoric Diester Hydrolases
Glucagon
GTP-Binding Proteins
Adenylyl Cyclases
Cyclic AMP
Hepatocytes
Signal Transduction
Phosphorylation

Keywords

  • glucagon
  • transducing pathways
  • hepatocytes

Cite this

Houslay, M. D., Bushfield, M., Kilgour, E., Lavan, B. E., Griffiths, S., Pyne, N., ... Murphy, G. (1990). Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase. In T. M. Konijn, M. D. Houslay, & P. J. M. van Haastert (Eds.), Activation and Desensitisation of Transducing Pathways (Vol. 44, pp. 63-83). (NATO ASI series). Springer-Verlag.
Houslay, M.D. ; Bushfield, M ; Kilgour, E ; Lavan, B E ; Griffiths, S ; Pyne, Nigel ; Tang, I ; Murphy, G. / Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase. Activation and Desensitisation of Transducing Pathways. editor / T.M. Konijn ; M.D. Houslay ; P.J.M. van Haastert. Vol. 44 Springer-Verlag, 1990. pp. 63-83 (NATO ASI series).
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author = "M.D. Houslay and M Bushfield and E Kilgour and Lavan, {B E} and S Griffiths and Nigel Pyne and I Tang and G Murphy",
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Houslay, MD, Bushfield, M, Kilgour, E, Lavan, BE, Griffiths, S, Pyne, N, Tang, I & Murphy, G 1990, Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase. in TM Konijn, MD Houslay & PJM van Haastert (eds), Activation and Desensitisation of Transducing Pathways. vol. 44, NATO ASI series, Springer-Verlag, pp. 63-83.

Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase. / Houslay, M.D.; Bushfield, M; Kilgour, E; Lavan, B E; Griffiths, S; Pyne, Nigel; Tang, I; Murphy, G.

Activation and Desensitisation of Transducing Pathways. ed. / T.M. Konijn; M.D. Houslay; P.J.M. van Haastert. Vol. 44 Springer-Verlag, 1990. p. 63-83 (NATO ASI series).

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

TY - CHAP

T1 - Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase

AU - Houslay, M.D.

AU - Bushfield, M

AU - Kilgour, E

AU - Lavan, B E

AU - Griffiths, S

AU - Pyne, Nigel

AU - Tang, I

AU - Murphy, G

PY - 1990

Y1 - 1990

N2 - Book chapter explains how glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase.

AB - Book chapter explains how glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase.

KW - glucagon

KW - transducing pathways

KW - hepatocytes

UR - http://www.springer.com/life+sciences/cell+biology/book/978-3-642-83620-6

M3 - Chapter (peer-reviewed)

SN - 9783642836183

VL - 44

T3 - NATO ASI series

SP - 63

EP - 83

BT - Activation and Desensitisation of Transducing Pathways

A2 - Konijn, T.M.

A2 - Houslay, M.D.

A2 - van Haastert, P.J.M.

PB - Springer-Verlag

ER -

Houslay MD, Bushfield M, Kilgour E, Lavan BE, Griffiths S, Pyne N et al. Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase. In Konijn TM, Houslay MD, van Haastert PJM, editors, Activation and Desensitisation of Transducing Pathways. Vol. 44. Springer-Verlag. 1990. p. 63-83. (NATO ASI series).

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