Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase

M.D. Houslay, M Bushfield, E Kilgour, B E Lavan, S Griffiths, Nigel Pyne, I Tang, G Murphy

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Abstract

Book chapter explains how glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase.
Original languageEnglish
Title of host publicationActivation and Desensitisation of Transducing Pathways
EditorsT.M. Konijn, M.D. Houslay, P.J.M. van Haastert
PublisherSpringer-Verlag
Pages63-83
Number of pages11
Volume44
ISBN (Print)9783642836183
Publication statusPublished - 1990

Publication series

NameNATO ASI series

Keywords

  • glucagon
  • transducing pathways
  • hepatocytes

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