Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase

M.D. Houslay; M Bushfield; E Kilgour; B E Lavan; S Griffiths; Nigel Pyne; I Tang; G Murphy

Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase

M.D. Houslay, M Bushfield, E Kilgour, B E Lavan, S Griffiths, Nigel Pyne, I Tang, G Murphy

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

Abstract

Book chapter explains how glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase.

Original language	English
Title of host publication	Activation and Desensitisation of Transducing Pathways
Editors	T.M. Konijn, M.D. Houslay, P.J.M. van Haastert
Publisher	Springer-Verlag
Pages	63-83
Number of pages	11
Volume	44
ISBN (Print)	9783642836183
Publication status	Published - 1990

Publication series

Name	NATO ASI series

Keywords

glucagon
transducing pathways
hepatocytes

Access to Document

http://www.springer.com/life+sciences/cell+biology/book/978-3-642-83620-6

Cite this

Houslay, M. D., Bushfield, M., Kilgour, E., Lavan, B. E., Griffiths, S., Pyne, N., Tang, I., & Murphy, G. (1990). Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase. In T. M. Konijn, M. D. Houslay, & P. J. M. van Haastert (Eds.), Activation and Desensitisation of Transducing Pathways (Vol. 44, pp. 63-83). (NATO ASI series). Springer-Verlag.

Houslay, M.D. ; Bushfield, M ; Kilgour, E ; Lavan, B E ; Griffiths, S ; Pyne, Nigel ; Tang, I ; Murphy, G. / Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase. Activation and Desensitisation of Transducing Pathways. editor / T.M. Konijn ; M.D. Houslay ; P.J.M. van Haastert. Vol. 44 Springer-Verlag, 1990. pp. 63-83 (NATO ASI series).

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title = "Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase",

abstract = "Book chapter explains how glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase.",

keywords = "glucagon, transducing pathways, hepatocytes",

author = "M.D. Houslay and M Bushfield and E Kilgour and Lavan, {B E} and S Griffiths and Nigel Pyne and I Tang and G Murphy",

year = "1990",

language = "English",

isbn = "9783642836183",

volume = "44",

series = "NATO ASI series",

publisher = "Springer-Verlag",

pages = "63--83",

editor = "T.M. Konijn and M.D. Houslay and {van Haastert}, P.J.M.",

booktitle = "Activation and Desensitisation of Transducing Pathways",

}

Houslay, MD, Bushfield, M, Kilgour, E, Lavan, BE, Griffiths, S, Pyne, N, Tang, I & Murphy, G 1990, Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase. in TM Konijn, MD Houslay & PJM van Haastert (eds), Activation and Desensitisation of Transducing Pathways. vol. 44, NATO ASI series, Springer-Verlag, pp. 63-83.

Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase. / Houslay, M.D.; Bushfield, M; Kilgour, E; Lavan, B E; Griffiths, S; Pyne, Nigel; Tang, I; Murphy, G.

Activation and Desensitisation of Transducing Pathways. ed. / T.M. Konijn; M.D. Houslay; P.J.M. van Haastert. Vol. 44 Springer-Verlag, 1990. p. 63-83 (NATO ASI series).

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

TY - CHAP

T1 - Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase

AU - Houslay, M.D.

AU - Bushfield, M

AU - Kilgour, E

AU - Lavan, B E

AU - Griffiths, S

AU - Pyne, Nigel

AU - Tang, I

AU - Murphy, G

PY - 1990

Y1 - 1990

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AB - Book chapter explains how glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase.

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KW - transducing pathways

KW - hepatocytes

UR - http://www.springer.com/life+sciences/cell+biology/book/978-3-642-83620-6

M3 - Chapter (peer-reviewed)

SN - 9783642836183

VL - 44

T3 - NATO ASI series

SP - 63

EP - 83

BT - Activation and Desensitisation of Transducing Pathways

A2 - Konijn, T.M.

A2 - Houslay, M.D.

A2 - van Haastert, P.J.M.

PB - Springer-Verlag

ER -

Houslay MD, Bushfield M, Kilgour E, Lavan BE, Griffiths S, Pyne N et al. Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase. In Konijn TM, Houslay MD, van Haastert PJM, editors, Activation and Desensitisation of Transducing Pathways. Vol. 44. Springer-Verlag. 1990. p. 63-83. (NATO ASI series).