Global sensitivity analysis of cell signal transduction networks based on morris method

J.F. Jia, H. Yue, T.Y. Liu, H. Wang, National Natural Science Foundation (Funder)

Research output: Contribution to journalArticle

Abstract

Cell signal transduction network structure and dynamics of complex uncertain parameters affect the dynamic characteristics of the system output and the parameters of how quantitative changes in the relationship and interactions between parameters, systems biology has become one of the important issues . to TNF-α induced NF-κB signal transduction network as object of study, by Morris method and its global sensitivity analysis technique to study the parameters on the output of the impact of NF-κBn to determine the parameters of the global sensitivity. Simulation results show that the system output NF-κBn for parameter θ28, θ36, θ52, θ61, θ9, θ29, θ19 and θ62 sensitive, so they affect NF = κBn the oscillation characteristics, suggesting that these parameters are NF-κB signal transduction network key rate constant .
Original languageEnglish
Pages (from-to)7-10
Number of pages3
JournalComputers and Applied Chemistry
Volume25
Issue number1
Publication statusPublished - Jan 2008

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Signal transduction
Sensitivity analysis
Rate constants

Keywords

  • global sensitivity analysis
  • cellular signal transduction networks
  • morris method

Cite this

Jia, J. F., Yue, H., Liu, T. Y., Wang, H., & National Natural Science Foundation (Funder) (2008). Global sensitivity analysis of cell signal transduction networks based on morris method. Computers and Applied Chemistry, 25(1), 7-10.
Jia, J.F. ; Yue, H. ; Liu, T.Y. ; Wang, H. ; National Natural Science Foundation (Funder). / Global sensitivity analysis of cell signal transduction networks based on morris method. In: Computers and Applied Chemistry. 2008 ; Vol. 25, No. 1. pp. 7-10.
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Jia, JF, Yue, H, Liu, TY, Wang, H & National Natural Science Foundation (Funder) 2008, 'Global sensitivity analysis of cell signal transduction networks based on morris method', Computers and Applied Chemistry, vol. 25, no. 1, pp. 7-10.

Global sensitivity analysis of cell signal transduction networks based on morris method. / Jia, J.F.; Yue, H.; Liu, T.Y.; Wang, H.; National Natural Science Foundation (Funder).

In: Computers and Applied Chemistry, Vol. 25, No. 1, 01.2008, p. 7-10.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Global sensitivity analysis of cell signal transduction networks based on morris method

AU - Jia, J.F.

AU - Yue, H.

AU - Liu, T.Y.

AU - Wang, H.

AU - National Natural Science Foundation (Funder)

PY - 2008/1

Y1 - 2008/1

N2 - Cell signal transduction network structure and dynamics of complex uncertain parameters affect the dynamic characteristics of the system output and the parameters of how quantitative changes in the relationship and interactions between parameters, systems biology has become one of the important issues . to TNF-α induced NF-κB signal transduction network as object of study, by Morris method and its global sensitivity analysis technique to study the parameters on the output of the impact of NF-κBn to determine the parameters of the global sensitivity. Simulation results show that the system output NF-κBn for parameter θ28, θ36, θ52, θ61, θ9, θ29, θ19 and θ62 sensitive, so they affect NF = κBn the oscillation characteristics, suggesting that these parameters are NF-κB signal transduction network key rate constant .

AB - Cell signal transduction network structure and dynamics of complex uncertain parameters affect the dynamic characteristics of the system output and the parameters of how quantitative changes in the relationship and interactions between parameters, systems biology has become one of the important issues . to TNF-α induced NF-κB signal transduction network as object of study, by Morris method and its global sensitivity analysis technique to study the parameters on the output of the impact of NF-κBn to determine the parameters of the global sensitivity. Simulation results show that the system output NF-κBn for parameter θ28, θ36, θ52, θ61, θ9, θ29, θ19 and θ62 sensitive, so they affect NF = κBn the oscillation characteristics, suggesting that these parameters are NF-κB signal transduction network key rate constant .

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KW - cellular signal transduction networks

KW - morris method

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Jia JF, Yue H, Liu TY, Wang H, National Natural Science Foundation (Funder). Global sensitivity analysis of cell signal transduction networks based on morris method. Computers and Applied Chemistry. 2008 Jan;25(1):7-10.