Projects per year
Abstract
The current Shigella sonnei pandemic involves geographically associated, multidrug resistant clones. This study has demonstrated that S. sonnei phylogeny can be accurately defined with limited SNPs. By typing 6 informative SNPs using high-resolution melting (HRM) assay major S. sonnei lineages/sublineages can be identified as defined from whole-genome variation.
Original language | English |
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Journal | Journal of Clinical Microbiology |
Early online date | 31 Oct 2012 |
DOIs | |
Publication status | Published - 1 Jan 2013 |
Keywords
- global phylogeny
- shigella sonnei
- single nucleotide polymorphisms
- snp-typing scheme
- strain identification
- high resolution
- melting analysis
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Dive into the research topics of 'Global phylogeny of Shigella sonnei from limited single nucleotide polymorphisms and development of a rapid and cost-effective SNP-typing scheme for strain identification by high resolution melting: rapid SNP-typing S. sonnei'. Together they form a unique fingerprint.Projects
- 1 Finished
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Genotyping epidemic Shigella sonnei
Yu, J. (Principal Investigator)
11/11/08 → 10/11/11
Project: Research
Research output
- 16 Citations
- 2 Article
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Rapid genotyping of Shigella sonnei using multiplex high resolution melting
Mazi, W., Sangal, V., Saeed, A., Sandstom, G., Weill , F.-X. & Yu, J., 29 Apr 2015, (E-pub ahead of print) In: Journal of Clinical Microbiology. 53, 7, p. 1-2 2 p., JCM.00874-15.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe
Holt, K., Baker, S., Weill, F.-X., Holmes, E. C., Kitchen, A., Yu, J., Sangal, V., Brown, D. J., Coia, J. E., Kim, D. W., Choi, S. Y., Kim, S. H., da Silveira, W. D., Pickard, D. J., Farrar, J. J., Parkhill, J., Dougan, G. & Thomson, N. R., Sept 2012, In: Nature Genetics. 44, 9, p. 1056–1059 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile226 Citations (Scopus)99 Downloads (Pure)