Geraniol as a novel antivirulence agent against bacillary dysentery-causing Shigella sonnei

Zainulabedeen R. M. H. Mirza, Thaer Hasan, Veronique Seidel, Jun Yu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Bacillary dysentery remains one of the most important diarrhoeal diseases affecting humans in the 21st century particularly in resource-poor nations. The etiological agents of this disease, Shigella bacteria, derive from diverse origins of Escherichia coli. Shigella sonnei is the causative agent for the current bacillary dysentery pandemic in many of the newly industrialised countries across all continents and has replaced Shigella flexneri, once the most prevalent species globally. Contemporary epidemic S. sonnei strains mostly belong to the lineage III and exhibit multiple drug resistance due to the spread of transposons and independent point mutations in the gyrase gene. In addition to that, developing an effective vaccine against Shigella remains a challenge. Hence, it has become urgent to seek alternative approaches to treat Shigella infection. Here, we show that geraniol, a natural substance present in the essential oils of plants such as rose and lemongrass can reduce S. sonnei proliferation inside host cells and protect Galleria mellonella larvae from killing by S. sonnei infection. We present evidence that geraniol competitively inhibits the catalytic activity of the master virulence regulator, DsbA, a periplasmic disulphide bond oxidoreductase required for Shigella survival in the host cell cytosol.
LanguageEnglish
Pages450-455
Number of pages12
JournalVirulence
Volume9
Issue number1
Early online date19 Dec 2017
DOIs
Publication statusPublished - 1 Mar 2018

Fingerprint

Shigella sonnei
Bacillary Dysentery
Shigella
Shigella Vaccines
Cymbopogon
Shigella flexneri
Multiple Drug Resistance
Pandemics
Volatile Oils
Infection
Point Mutation
Developed Countries
Disulfides
Cytosol
Larva
Virulence
Oxidoreductases
Escherichia coli
Bacteria
Survival

Keywords

  • Shigella sonnei
  • bacillary dysentery
  • geraniol
  • antivirulence
  • antibiotic resistance

Cite this

@article{aa547790b3464c6bab275afd52eb0b10,
title = "Geraniol as a novel antivirulence agent against bacillary dysentery-causing Shigella sonnei",
abstract = "Bacillary dysentery remains one of the most important diarrhoeal diseases affecting humans in the 21st century particularly in resource-poor nations. The etiological agents of this disease, Shigella bacteria, derive from diverse origins of Escherichia coli. Shigella sonnei is the causative agent for the current bacillary dysentery pandemic in many of the newly industrialised countries across all continents and has replaced Shigella flexneri, once the most prevalent species globally. Contemporary epidemic S. sonnei strains mostly belong to the lineage III and exhibit multiple drug resistance due to the spread of transposons and independent point mutations in the gyrase gene. In addition to that, developing an effective vaccine against Shigella remains a challenge. Hence, it has become urgent to seek alternative approaches to treat Shigella infection. Here, we show that geraniol, a natural substance present in the essential oils of plants such as rose and lemongrass can reduce S. sonnei proliferation inside host cells and protect Galleria mellonella larvae from killing by S. sonnei infection. We present evidence that geraniol competitively inhibits the catalytic activity of the master virulence regulator, DsbA, a periplasmic disulphide bond oxidoreductase required for Shigella survival in the host cell cytosol.",
keywords = "Shigella sonnei, bacillary dysentery, geraniol, antivirulence, antibiotic resistance",
author = "Mirza, {Zainulabedeen R. M. H.} and Thaer Hasan and Veronique Seidel and Jun Yu",
year = "2018",
month = "3",
day = "1",
doi = "10.1080/21505594.2017.1412031",
language = "English",
volume = "9",
pages = "450--455",
journal = "Virulence",
issn = "2150-5594",
number = "1",

}

Geraniol as a novel antivirulence agent against bacillary dysentery-causing Shigella sonnei. / Mirza, Zainulabedeen R. M. H.; Hasan, Thaer; Seidel, Veronique; Yu, Jun.

In: Virulence, Vol. 9, No. 1, 01.03.2018, p. 450-455.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Geraniol as a novel antivirulence agent against bacillary dysentery-causing Shigella sonnei

AU - Mirza, Zainulabedeen R. M. H.

AU - Hasan, Thaer

AU - Seidel, Veronique

AU - Yu, Jun

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Bacillary dysentery remains one of the most important diarrhoeal diseases affecting humans in the 21st century particularly in resource-poor nations. The etiological agents of this disease, Shigella bacteria, derive from diverse origins of Escherichia coli. Shigella sonnei is the causative agent for the current bacillary dysentery pandemic in many of the newly industrialised countries across all continents and has replaced Shigella flexneri, once the most prevalent species globally. Contemporary epidemic S. sonnei strains mostly belong to the lineage III and exhibit multiple drug resistance due to the spread of transposons and independent point mutations in the gyrase gene. In addition to that, developing an effective vaccine against Shigella remains a challenge. Hence, it has become urgent to seek alternative approaches to treat Shigella infection. Here, we show that geraniol, a natural substance present in the essential oils of plants such as rose and lemongrass can reduce S. sonnei proliferation inside host cells and protect Galleria mellonella larvae from killing by S. sonnei infection. We present evidence that geraniol competitively inhibits the catalytic activity of the master virulence regulator, DsbA, a periplasmic disulphide bond oxidoreductase required for Shigella survival in the host cell cytosol.

AB - Bacillary dysentery remains one of the most important diarrhoeal diseases affecting humans in the 21st century particularly in resource-poor nations. The etiological agents of this disease, Shigella bacteria, derive from diverse origins of Escherichia coli. Shigella sonnei is the causative agent for the current bacillary dysentery pandemic in many of the newly industrialised countries across all continents and has replaced Shigella flexneri, once the most prevalent species globally. Contemporary epidemic S. sonnei strains mostly belong to the lineage III and exhibit multiple drug resistance due to the spread of transposons and independent point mutations in the gyrase gene. In addition to that, developing an effective vaccine against Shigella remains a challenge. Hence, it has become urgent to seek alternative approaches to treat Shigella infection. Here, we show that geraniol, a natural substance present in the essential oils of plants such as rose and lemongrass can reduce S. sonnei proliferation inside host cells and protect Galleria mellonella larvae from killing by S. sonnei infection. We present evidence that geraniol competitively inhibits the catalytic activity of the master virulence regulator, DsbA, a periplasmic disulphide bond oxidoreductase required for Shigella survival in the host cell cytosol.

KW - Shigella sonnei

KW - bacillary dysentery

KW - geraniol

KW - antivirulence

KW - antibiotic resistance

UR - http://www.tandfonline.com/toc/kvir20/current

U2 - 10.1080/21505594.2017.1412031

DO - 10.1080/21505594.2017.1412031

M3 - Article

VL - 9

SP - 450

EP - 455

JO - Virulence

T2 - Virulence

JF - Virulence

SN - 2150-5594

IS - 1

ER -