Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non-Hodgkin lymphoma

Xiaofeng Bi, Tongzhang Zheng, Qing Lan, Zhijian Xu, Yingtai Chen, Gongjian Zhu, Francine Foss, Christopher Kim, Min Dai, Ping Zhao, Theodore Holford, Brian Leaderer, Peter Boyle, Qian Deng, Stephen J Chanock, Nathaniel Rothman, Yawei Zhang

Research output: Contribution to journalArticle

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Abstract

We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in Th1 and Th2 cytokine genes may modify the association between blood transfusion and risk of non-Hodgkin lymphoma (NHL). Compared with women without blood transfusion, women with a history of transfusion had an increased risk of NHL if they carried IL10RA (rs9610) GG genotype [odds ratio (OR) = 1.9, 95% confidence interval (CI): 1.1-3.2] or TNF (rs1800629) AG/AA genotypes (OR = 1.6, 95% CI: 0.9-2.7). We also found women with a history of transfusion had a decreased risk of NHL if they carried IL10RA (rs9610) AG/AA genotypes (OR = 0.6, 95% CI: 0.4-0.9) or TNF (rs1800629) GG genotype (OR = 0.7, 95% CI: 0.5-1.0). A similar pattern was also observed for B-cell lymphoma but not for T-cell lymphoma. Statistically significant interactions with blood transfusion were observed for IL10RA (rs9610) (P(forinteraction) = 0.003) and TNF (rs1800629) (P(forinteraction) = 0.012) for NHL overall and IL10RA (rs9610) (P(forinteraction) = 0.001) and TNF (rs1800629) (P(forinteraction) = 0.019) for B-cell lymphoma. The results suggest that genetic polymorphisms in TNF and IL10RA genes may modify the association between blood transfusion and NHL risk.
LanguageEnglish
Pages766-769
Number of pages4
JournalAmerican journal of hematology
Volume87
Issue number8
Early online date31 May 2012
DOIs
Publication statusPublished - Aug 2012

Fingerprint

Genetic Polymorphisms
Blood Transfusion
Non-Hodgkin's Lymphoma
Odds Ratio
Genotype
Confidence Intervals
B-Cell Lymphoma
T-Cell Lymphoma
Genes
Case-Control Studies
Cytokines
Population

Keywords

  • interleukin-10 receptor alpha subunit
  • tumor necrosis factor-alpha
  • polymorphism, genetic
  • humans
  • retrospective studies
  • aged
  • connecticut
  • lymphoma, B-cell
  • aged, 80 and over
  • risk factors
  • adult
  • blood transfusion
  • middle aged
  • Female

Cite this

Bi, Xiaofeng ; Zheng, Tongzhang ; Lan, Qing ; Xu, Zhijian ; Chen, Yingtai ; Zhu, Gongjian ; Foss, Francine ; Kim, Christopher ; Dai, Min ; Zhao, Ping ; Holford, Theodore ; Leaderer, Brian ; Boyle, Peter ; Deng, Qian ; Chanock, Stephen J ; Rothman, Nathaniel ; Zhang, Yawei. / Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non-Hodgkin lymphoma. In: American journal of hematology. 2012 ; Vol. 87, No. 8. pp. 766-769.
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abstract = "We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in Th1 and Th2 cytokine genes may modify the association between blood transfusion and risk of non-Hodgkin lymphoma (NHL). Compared with women without blood transfusion, women with a history of transfusion had an increased risk of NHL if they carried IL10RA (rs9610) GG genotype [odds ratio (OR) = 1.9, 95{\%} confidence interval (CI): 1.1-3.2] or TNF (rs1800629) AG/AA genotypes (OR = 1.6, 95{\%} CI: 0.9-2.7). We also found women with a history of transfusion had a decreased risk of NHL if they carried IL10RA (rs9610) AG/AA genotypes (OR = 0.6, 95{\%} CI: 0.4-0.9) or TNF (rs1800629) GG genotype (OR = 0.7, 95{\%} CI: 0.5-1.0). A similar pattern was also observed for B-cell lymphoma but not for T-cell lymphoma. Statistically significant interactions with blood transfusion were observed for IL10RA (rs9610) (P(forinteraction) = 0.003) and TNF (rs1800629) (P(forinteraction) = 0.012) for NHL overall and IL10RA (rs9610) (P(forinteraction) = 0.001) and TNF (rs1800629) (P(forinteraction) = 0.019) for B-cell lymphoma. The results suggest that genetic polymorphisms in TNF and IL10RA genes may modify the association between blood transfusion and NHL risk.",
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author = "Xiaofeng Bi and Tongzhang Zheng and Qing Lan and Zhijian Xu and Yingtai Chen and Gongjian Zhu and Francine Foss and Christopher Kim and Min Dai and Ping Zhao and Theodore Holford and Brian Leaderer and Peter Boyle and Qian Deng and Chanock, {Stephen J} and Nathaniel Rothman and Yawei Zhang",
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Bi, X, Zheng, T, Lan, Q, Xu, Z, Chen, Y, Zhu, G, Foss, F, Kim, C, Dai, M, Zhao, P, Holford, T, Leaderer, B, Boyle, P, Deng, Q, Chanock, SJ, Rothman, N & Zhang, Y 2012, 'Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non-Hodgkin lymphoma' American journal of hematology, vol. 87, no. 8, pp. 766-769. https://doi.org/10.1002/ajh.23244

Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non-Hodgkin lymphoma. / Bi, Xiaofeng; Zheng, Tongzhang; Lan, Qing; Xu, Zhijian; Chen, Yingtai; Zhu, Gongjian; Foss, Francine; Kim, Christopher; Dai, Min; Zhao, Ping; Holford, Theodore; Leaderer, Brian; Boyle, Peter; Deng, Qian; Chanock, Stephen J; Rothman, Nathaniel; Zhang, Yawei.

In: American journal of hematology, Vol. 87, No. 8, 08.2012, p. 766-769.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non-Hodgkin lymphoma

AU - Bi, Xiaofeng

AU - Zheng, Tongzhang

AU - Lan, Qing

AU - Xu, Zhijian

AU - Chen, Yingtai

AU - Zhu, Gongjian

AU - Foss, Francine

AU - Kim, Christopher

AU - Dai, Min

AU - Zhao, Ping

AU - Holford, Theodore

AU - Leaderer, Brian

AU - Boyle, Peter

AU - Deng, Qian

AU - Chanock, Stephen J

AU - Rothman, Nathaniel

AU - Zhang, Yawei

PY - 2012/8

Y1 - 2012/8

N2 - We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in Th1 and Th2 cytokine genes may modify the association between blood transfusion and risk of non-Hodgkin lymphoma (NHL). Compared with women without blood transfusion, women with a history of transfusion had an increased risk of NHL if they carried IL10RA (rs9610) GG genotype [odds ratio (OR) = 1.9, 95% confidence interval (CI): 1.1-3.2] or TNF (rs1800629) AG/AA genotypes (OR = 1.6, 95% CI: 0.9-2.7). We also found women with a history of transfusion had a decreased risk of NHL if they carried IL10RA (rs9610) AG/AA genotypes (OR = 0.6, 95% CI: 0.4-0.9) or TNF (rs1800629) GG genotype (OR = 0.7, 95% CI: 0.5-1.0). A similar pattern was also observed for B-cell lymphoma but not for T-cell lymphoma. Statistically significant interactions with blood transfusion were observed for IL10RA (rs9610) (P(forinteraction) = 0.003) and TNF (rs1800629) (P(forinteraction) = 0.012) for NHL overall and IL10RA (rs9610) (P(forinteraction) = 0.001) and TNF (rs1800629) (P(forinteraction) = 0.019) for B-cell lymphoma. The results suggest that genetic polymorphisms in TNF and IL10RA genes may modify the association between blood transfusion and NHL risk.

AB - We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in Th1 and Th2 cytokine genes may modify the association between blood transfusion and risk of non-Hodgkin lymphoma (NHL). Compared with women without blood transfusion, women with a history of transfusion had an increased risk of NHL if they carried IL10RA (rs9610) GG genotype [odds ratio (OR) = 1.9, 95% confidence interval (CI): 1.1-3.2] or TNF (rs1800629) AG/AA genotypes (OR = 1.6, 95% CI: 0.9-2.7). We also found women with a history of transfusion had a decreased risk of NHL if they carried IL10RA (rs9610) AG/AA genotypes (OR = 0.6, 95% CI: 0.4-0.9) or TNF (rs1800629) GG genotype (OR = 0.7, 95% CI: 0.5-1.0). A similar pattern was also observed for B-cell lymphoma but not for T-cell lymphoma. Statistically significant interactions with blood transfusion were observed for IL10RA (rs9610) (P(forinteraction) = 0.003) and TNF (rs1800629) (P(forinteraction) = 0.012) for NHL overall and IL10RA (rs9610) (P(forinteraction) = 0.001) and TNF (rs1800629) (P(forinteraction) = 0.019) for B-cell lymphoma. The results suggest that genetic polymorphisms in TNF and IL10RA genes may modify the association between blood transfusion and NHL risk.

KW - interleukin-10 receptor alpha subunit

KW - tumor necrosis factor-alpha

KW - polymorphism, genetic

KW - humans

KW - retrospective studies

KW - aged

KW - connecticut

KW - lymphoma, B-cell

KW - aged, 80 and over

KW - risk factors

KW - adult

KW - blood transfusion

KW - middle aged

KW - Female

UR - http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1096-8652

U2 - 10.1002/ajh.23244

DO - 10.1002/ajh.23244

M3 - Article

VL - 87

SP - 766

EP - 769

JO - American journal of hematology

T2 - American journal of hematology

JF - American journal of hematology

SN - 0361-8609

IS - 8

ER -