Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non-Hodgkin lymphoma

Xiaofeng Bi, Tongzhang Zheng, Qing Lan, Zhijian Xu, Yingtai Chen, Gongjian Zhu, Francine Foss, Christopher Kim, Min Dai, Ping Zhao, Theodore Holford, Brian Leaderer, Peter Boyle, Qian Deng, Stephen J Chanock, Nathaniel Rothman, Yawei Zhang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in Th1 and Th2 cytokine genes may modify the association between blood transfusion and risk of non-Hodgkin lymphoma (NHL). Compared with women without blood transfusion, women with a history of transfusion had an increased risk of NHL if they carried IL10RA (rs9610) GG genotype [odds ratio (OR) = 1.9, 95% confidence interval (CI): 1.1-3.2] or TNF (rs1800629) AG/AA genotypes (OR = 1.6, 95% CI: 0.9-2.7). We also found women with a history of transfusion had a decreased risk of NHL if they carried IL10RA (rs9610) AG/AA genotypes (OR = 0.6, 95% CI: 0.4-0.9) or TNF (rs1800629) GG genotype (OR = 0.7, 95% CI: 0.5-1.0). A similar pattern was also observed for B-cell lymphoma but not for T-cell lymphoma. Statistically significant interactions with blood transfusion were observed for IL10RA (rs9610) (P(forinteraction) = 0.003) and TNF (rs1800629) (P(forinteraction) = 0.012) for NHL overall and IL10RA (rs9610) (P(forinteraction) = 0.001) and TNF (rs1800629) (P(forinteraction) = 0.019) for B-cell lymphoma. The results suggest that genetic polymorphisms in TNF and IL10RA genes may modify the association between blood transfusion and NHL risk.
Original languageEnglish
Pages (from-to)766-769
Number of pages4
JournalAmerican journal of hematology
Volume87
Issue number8
Early online date31 May 2012
DOIs
Publication statusPublished - Aug 2012

Keywords

  • interleukin-10 receptor alpha subunit
  • tumor necrosis factor-alpha
  • polymorphism, genetic
  • humans
  • retrospective studies
  • aged
  • connecticut
  • lymphoma, B-cell
  • aged, 80 and over
  • risk factors
  • adult
  • blood transfusion
  • middle aged
  • Female

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