GeneRank: using search engine technology for the analysis of microarray experiments

Julie L Morrison, Rainer Breitling, Desmond J Higham, David R Gilbert

Research output: Contribution to journalArticle

176 Citations (Scopus)
9 Downloads (Pure)

Abstract

Interpretation of simple microarray experiments is usually based on the fold-change of gene expression between a reference and a 'treated' sample where the treatment can be of many types from drug exposure to genetic variation. Interpretation of the results usually combines lists of differentially expressed genes with previous knowledge about their biological function. Here we evaluate a method - based on the PageRank algorithm employed by the popular search engine Google - that tries to automate some of this procedure to generate prioritized gene lists by exploiting biological background information.
Original languageEnglish
Pages (from-to)233
JournalBMC Bioinformatics
Volume6
Issue number1
DOIs
Publication statusPublished - 21 Sep 2005

Keywords

  • microarray experiments
  • gene expression
  • generank
  • physics

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