Gene manipulation to enhance MIBG-targeted radionuclide therapy

Robert J. Mairs; Natasha E. Fullerton; Emilio Cosimo; Marie Boyd

doi:10.1016/j.nucmedbio.2005.03.011

Gene manipulation to enhance MIBG-targeted radionuclide therapy

Robert J. Mairs^*
, Natasha E. Fullerton
, Emilio Cosimo
, Marie Boyd

^*Corresponding author for this work

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The goal of targeted radionuclide therapy is the deposition in malignant cells of sterilizing doses of radiation without damaging normal tissue. The radiopharmaceutical [¹³¹I]meta-iodobenzylguanidine ([ ¹³¹I]MIBG) is an effective single agent for the treatment of neuroblastoma. However, uptake of the drug in malignant sites is insufficient to cure disease. A growing body of experimental evidence indicates exciting possibilities for the integration of gene transfer with [¹³¹I]MIBG- targeted radiotherapy.

Original language	English
Pages (from-to)	749-753
Number of pages	5
Journal	Nuclear Medicine and Biology
Volume	32
Issue number	7
Early online date	21 Oct 2005
DOIs	https://doi.org/10.1016/j.nucmedbio.2005.03.011
Publication status	Published - 21 Oct 2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

gene therapy
MIBG
noradrenaline transporter
targeted radiotherapy

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10.1016/j.nucmedbio.2005.03.011

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title = "Gene manipulation to enhance MIBG-targeted radionuclide therapy",

abstract = "The goal of targeted radionuclide therapy is the deposition in malignant cells of sterilizing doses of radiation without damaging normal tissue. The radiopharmaceutical [131I]meta-iodobenzylguanidine ([ 131I]MIBG) is an effective single agent for the treatment of neuroblastoma. However, uptake of the drug in malignant sites is insufficient to cure disease. A growing body of experimental evidence indicates exciting possibilities for the integration of gene transfer with [131I]MIBG- targeted radiotherapy.",

keywords = "gene therapy, MIBG, noradrenaline transporter, targeted radiotherapy",

author = "Mairs, \{Robert J.\} and Fullerton, \{Natasha E.\} and Emilio Cosimo and Marie Boyd",

year = "2005",

month = oct,

day = "21",

doi = "10.1016/j.nucmedbio.2005.03.011",

language = "English",

volume = "32",

pages = "749--753",

journal = "Nuclear Medicine and Biology",

issn = "0969-8051",

publisher = "Elsevier Inc.",

number = "7",

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TY - JOUR

T1 - Gene manipulation to enhance MIBG-targeted radionuclide therapy

AU - Mairs, Robert J.

AU - Fullerton, Natasha E.

AU - Cosimo, Emilio

AU - Boyd, Marie

PY - 2005/10/21

Y1 - 2005/10/21

N2 - The goal of targeted radionuclide therapy is the deposition in malignant cells of sterilizing doses of radiation without damaging normal tissue. The radiopharmaceutical [131I]meta-iodobenzylguanidine ([ 131I]MIBG) is an effective single agent for the treatment of neuroblastoma. However, uptake of the drug in malignant sites is insufficient to cure disease. A growing body of experimental evidence indicates exciting possibilities for the integration of gene transfer with [131I]MIBG- targeted radiotherapy.

AB - The goal of targeted radionuclide therapy is the deposition in malignant cells of sterilizing doses of radiation without damaging normal tissue. The radiopharmaceutical [131I]meta-iodobenzylguanidine ([ 131I]MIBG) is an effective single agent for the treatment of neuroblastoma. However, uptake of the drug in malignant sites is insufficient to cure disease. A growing body of experimental evidence indicates exciting possibilities for the integration of gene transfer with [131I]MIBG- targeted radiotherapy.

KW - gene therapy

KW - MIBG

KW - noradrenaline transporter

KW - targeted radiotherapy

UR - https://www.scopus.com/pages/publications/27144507056

U2 - 10.1016/j.nucmedbio.2005.03.011

DO - 10.1016/j.nucmedbio.2005.03.011

M3 - Article

C2 - 16243651

AN - SCOPUS:27144507056

SN - 0969-8051

VL - 32

SP - 749

EP - 753

JO - Nuclear Medicine and Biology

JF - Nuclear Medicine and Biology

IS - 7

ER -

Gene manipulation to enhance MIBG-targeted radionuclide therapy

Abstract

UN SDGs

Keywords

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