Galactosylated poly(ethylene glycol) as a scaffold for primary hepatocytes.

C Hamilton; C J Henderson; R V Ulijn; M H Grant

Abstract

Maintaining stable cultures of viable and metabolically active primary hepatocytes is a long standing problem 1. Synthetic biomaterials with tuneable chemical properties may provide a suitable platform for the culture of primary cells. Hepatocytes are capable of binding terminal galactose residues via the hepatocyte asialoglycoprotein receptor (ASGPr); targeting of this receptor may facilitate binding of cells, influence morphology and ultimately improve cellular function 2

Original language	English
Pages (from-to)	30
Number of pages	1
Journal	European Cells and Materials
Volume	23
Issue number	Suppl 4
Publication status	Published - Jul 2012
Event	Tissue and Cell Engineering Society (TCES) meeting - Liverpool, United Kingdom Duration: 4 Jul 2012 → 6 Jul 2012

Keywords

hepatocyte scaffold
galactosylated poly(ethylene glycol)
stable cultures

Cite this

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title = "Galactosylated poly(ethylene glycol) as a scaffold for primary hepatocytes.",

abstract = "Maintaining stable cultures of viable and metabolically active primary hepatocytes is a long standing problem 1. Synthetic biomaterials with tuneable chemical properties may provide a suitable platform for the culture of primary cells. Hepatocytes are capable of binding terminal galactose residues via the hepatocyte asialoglycoprotein receptor (ASGPr); targeting of this receptor may facilitate binding of cells, influence morphology and ultimately improve cellular function 2 ",

keywords = "hepatocyte scaffold, galactosylated poly(ethylene glycol), stable cultures",

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T1 - Galactosylated poly(ethylene glycol) as a scaffold for primary hepatocytes.

AU - Hamilton, C

AU - Henderson, C J

AU - Ulijn, R V

AU - Grant, M H

PY - 2012/7

Y1 - 2012/7

N2 - Maintaining stable cultures of viable and metabolically active primary hepatocytes is a long standing problem 1. Synthetic biomaterials with tuneable chemical properties may provide a suitable platform for the culture of primary cells. Hepatocytes are capable of binding terminal galactose residues via the hepatocyte asialoglycoprotein receptor (ASGPr); targeting of this receptor may facilitate binding of cells, influence morphology and ultimately improve cellular function 2

AB - Maintaining stable cultures of viable and metabolically active primary hepatocytes is a long standing problem 1. Synthetic biomaterials with tuneable chemical properties may provide a suitable platform for the culture of primary cells. Hepatocytes are capable of binding terminal galactose residues via the hepatocyte asialoglycoprotein receptor (ASGPr); targeting of this receptor may facilitate binding of cells, influence morphology and ultimately improve cellular function 2

KW - hepatocyte scaffold

KW - galactosylated poly(ethylene glycol)

KW - stable cultures

UR - http://www.ecmjournal.org/journal/supplements/vol023supp04/vol023supp04.htm

M3 - Conference abstract

SN - 1473-2262

VL - 23

SP - 30

JO - European Cells and Materials

JF - European Cells and Materials

IS - Suppl 4

T2 - Tissue and Cell Engineering Society (TCES) meeting

Y2 - 4 July 2012 through 6 July 2012

ER -

Galactosylated poly(ethylene glycol) as a scaffold for primary hepatocytes.

Abstract

Keywords

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