Galactosylated poly(ethylene glycol) as a scaffold for primary hepatocytes.

Research output: Contribution to journalMeeting abstract

Abstract

Maintaining stable cultures of viable and metabolically active primary hepatocytes is a long standing problem 1. Synthetic biomaterials with tuneable chemical properties may provide a suitable platform for the culture of primary cells. Hepatocytes are capable of binding terminal galactose residues via the hepatocyte asialoglycoprotein receptor (ASGPr); targeting of this receptor may facilitate binding of cells, influence morphology and ultimately improve cellular function 2
Original languageEnglish
Pages (from-to)30
Number of pages1
JournalEuropean Cells and Materials
Volume23
Issue numberSuppl 4
Publication statusPublished - Jul 2012
EventTissue and Cell Engineering Society (TCES) meeting - Liverpool, United Kingdom
Duration: 4 Jul 20126 Jul 2012

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Ethylene Glycol
Scaffolds
Polyethylene glycols
Hepatocytes
Asialoglycoprotein Receptor
Primary Cell Culture
Biocompatible Materials
Galactose
Biomaterials
Chemical properties

Keywords

  • hepatocyte scaffold
  • galactosylated poly(ethylene glycol)
  • stable cultures

Cite this

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title = "Galactosylated poly(ethylene glycol) as a scaffold for primary hepatocytes.",
abstract = "Maintaining stable cultures of viable and metabolically active primary hepatocytes is a long standing problem 1. Synthetic biomaterials with tuneable chemical properties may provide a suitable platform for the culture of primary cells. Hepatocytes are capable of binding terminal galactose residues via the hepatocyte asialoglycoprotein receptor (ASGPr); targeting of this receptor may facilitate binding of cells, influence morphology and ultimately improve cellular function 2",
keywords = "hepatocyte scaffold, galactosylated poly(ethylene glycol), stable cultures",
author = "C Hamilton and Henderson, {C J} and Ulijn, {R V} and Grant, {M H}",
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language = "English",
volume = "23",
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journal = "European Cells and Materials",
issn = "1473-2262",
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}

Galactosylated poly(ethylene glycol) as a scaffold for primary hepatocytes. / Hamilton, C; Henderson, C J; Ulijn, R V; Grant, M H.

In: European Cells and Materials, Vol. 23, No. Suppl 4, 07.2012, p. 30.

Research output: Contribution to journalMeeting abstract

TY - JOUR

T1 - Galactosylated poly(ethylene glycol) as a scaffold for primary hepatocytes.

AU - Hamilton, C

AU - Henderson, C J

AU - Ulijn, R V

AU - Grant, M H

PY - 2012/7

Y1 - 2012/7

N2 - Maintaining stable cultures of viable and metabolically active primary hepatocytes is a long standing problem 1. Synthetic biomaterials with tuneable chemical properties may provide a suitable platform for the culture of primary cells. Hepatocytes are capable of binding terminal galactose residues via the hepatocyte asialoglycoprotein receptor (ASGPr); targeting of this receptor may facilitate binding of cells, influence morphology and ultimately improve cellular function 2

AB - Maintaining stable cultures of viable and metabolically active primary hepatocytes is a long standing problem 1. Synthetic biomaterials with tuneable chemical properties may provide a suitable platform for the culture of primary cells. Hepatocytes are capable of binding terminal galactose residues via the hepatocyte asialoglycoprotein receptor (ASGPr); targeting of this receptor may facilitate binding of cells, influence morphology and ultimately improve cellular function 2

KW - hepatocyte scaffold

KW - galactosylated poly(ethylene glycol)

KW - stable cultures

UR - http://www.ecmjournal.org/journal/supplements/vol023supp04/vol023supp04.htm

M3 - Meeting abstract

VL - 23

SP - 30

JO - European Cells and Materials

JF - European Cells and Materials

SN - 1473-2262

IS - Suppl 4

ER -