Abstract
| Original language | Undefined/Unknown |
|---|---|
| Pages | ORGN-027 |
| Publication status | Published - 2000 |
| Event | 219th Meeting of the American Chemical Society - San Francisco, United States Duration: 26 Mar 2000 → 30 Mar 2000 |
Conference
| Conference | 219th Meeting of the American Chemical Society |
|---|---|
| Country | United States |
| City | San Francisco |
| Period | 26/03/00 → 30/03/00 |
Keywords
- synthesis
- 24(s)
- 25-epoxycholesterol
- efficient perparation
- desmosterol
Cite this
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Further studies on synthesis of 24(S),25-epoxycholesterol : new efficient preparation of desmosterol. / Spencer Thomas A., Jr.; Li, Dansu; Russel, Jonathon S.; Tomkinson, Nicholas C. O.; Willson, Timothy M.
2000. ORGN-027 Abstract from 219th Meeting of the American Chemical Society, San Francisco, United States.Research output: Contribution to conference › Abstract
TY - CONF
T1 - Further studies on synthesis of 24(S),25-epoxycholesterol
T2 - new efficient preparation of desmosterol
AU - Spencer Thomas A., Jr.
AU - Li, Dansu
AU - Russel, Jonathon S.
AU - Tomkinson, Nicholas C. O.
AU - Willson, Timothy M.
N1 - CAPLUS AN 2000:332149(Conference; Meeting Abstract)
PY - 2000
Y1 - 2000
N2 - Our synthesis of the regulatory oxysterol 24(S),25-epoxycholesterol (1) from stigmasterol has been improved by the discovery that cuprate 2 can be coupled with allylic acetate 3 to give in 73% yield in the key step of the most effecient conversion yet of a C22 intermediate to desmosteryl acetate (4). Efforts to prep. diol 5 from sulfone 6 via Payne rearrangement of epoxide 7 will also be presented. [on SciFinder(R)]
AB - Our synthesis of the regulatory oxysterol 24(S),25-epoxycholesterol (1) from stigmasterol has been improved by the discovery that cuprate 2 can be coupled with allylic acetate 3 to give in 73% yield in the key step of the most effecient conversion yet of a C22 intermediate to desmosteryl acetate (4). Efforts to prep. diol 5 from sulfone 6 via Payne rearrangement of epoxide 7 will also be presented. [on SciFinder(R)]
KW - synthesis
KW - 24(s)
KW - 25-epoxycholesterol
KW - efficient perparation
KW - desmosterol
M3 - Abstract
SP - ORGN-027
ER -