Functionalized main-group organometallics for organic synthesis

Paul  Knochel; Eike Hupe; Wolfgang Dohle; David M. Lindsay; Véronique  Bonnet; Guy  Quéguiner; Andreas Boudier; Felix Kopp; Stéphane  Demay; Naka  Seidel; M. Isabel Calaza; Viet Anh  Vu; Ioannis  Sapountzis; Tanasri  Bunlaksananusorn

doi:10.1351/pac200274010011

Functionalized main-group organometallics for organic synthesis

Paul Knochel, Eike Hupe, Wolfgang Dohle, David M. Lindsay, Véronique Bonnet, Guy Quéguiner, Andreas Boudier, Felix Kopp, Stéphane Demay, Naka Seidel, M. Isabel Calaza, Viet Anh Vu, Ioannis Sapountzis , Tanasri Bunlaksananusorn

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

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Abstract

Highly functionalized Grignard-reagents can be easily obtained by an iodine–magnesium exchange reaction and further reacted with various electrophiles. Via a B–Zn exchange reaction, a formal Michael addition with umpolung of the reactivity can be achieved. Chiral phosphine ligands can be easily synthesized by a 2.3 sigmatropic rearrangement and used successfully in asymmetric synthesis.

Original language	English
Pages (from-to)	11-17
Number of pages	7
Journal	Pure and Applied Chemistry
Volume	74
Issue number	1
DOIs	https://doi.org/10.1351/pac200274010011
Publication status	Published - 1 Jan 2002

Keywords

organometallics
main-group organometallics
organic synthesis

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Knochel-etal-PAC2002-Functionalized-main-group-organometallics-organic-synthesisFinal published version, 276 KB

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title = "Functionalized main-group organometallics for organic synthesis",

abstract = "Highly functionalized Grignard-reagents can be easily obtained by an iodine–magnesium exchange reaction and further reacted with various electrophiles. Via a B–Zn exchange reaction, a formal Michael addition with umpolung of the reactivity can be achieved. Chiral phosphine ligands can be easily synthesized by a 2.3 sigmatropic rearrangement and used successfully in asymmetric synthesis.",

keywords = "organometallics, main-group organometallics, organic synthesis",

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doi = "10.1351/pac200274010011",

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T1 - Functionalized main-group organometallics for organic synthesis

AU - Knochel, Paul

AU - Hupe, Eike

AU - Dohle, Wolfgang

AU - Lindsay, David M.

AU - Bonnet, Véronique

AU - Quéguiner, Guy

AU - Boudier, Andreas

AU - Kopp, Felix

AU - Demay, Stéphane

AU - Seidel, Naka

AU - Calaza, M. Isabel

AU - Vu, Viet Anh

AU - Sapountzis , Ioannis

AU - Bunlaksananusorn, Tanasri

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Highly functionalized Grignard-reagents can be easily obtained by an iodine–magnesium exchange reaction and further reacted with various electrophiles. Via a B–Zn exchange reaction, a formal Michael addition with umpolung of the reactivity can be achieved. Chiral phosphine ligands can be easily synthesized by a 2.3 sigmatropic rearrangement and used successfully in asymmetric synthesis.

AB - Highly functionalized Grignard-reagents can be easily obtained by an iodine–magnesium exchange reaction and further reacted with various electrophiles. Via a B–Zn exchange reaction, a formal Michael addition with umpolung of the reactivity can be achieved. Chiral phosphine ligands can be easily synthesized by a 2.3 sigmatropic rearrangement and used successfully in asymmetric synthesis.

KW - organometallics

KW - main-group organometallics

KW - organic synthesis

U2 - 10.1351/pac200274010011

DO - 10.1351/pac200274010011

M3 - Article

SN - 1365-3075

VL - 74

SP - 11

EP - 17

JO - Pure and Applied Chemistry

JF - Pure and Applied Chemistry

IS - 1

ER -

Functionalized main-group organometallics for organic synthesis

Abstract

Keywords

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