Functionalising the azobenzene motif delivers a light-responsive membrane-interactive compound with the potential for photodynamic therapy applications

Theodore J. Hester, Sarah R. Dennison, Matthew J. Baker, Timothy J. Snape

Research output: Contribution to journalArticle

6 Citations (Scopus)
95 Downloads (Pure)

Abstract

When adorned with n-octyl chains azobenzene is able to disrupt a variety of calcein-loaded phospholipid liposomes. The levels of lysis observed are dependent both on the lipid headgroup and the conformation of the azobenzene compound. In all cases studied, it has been shown that the cis-conformer is more membrane-interactive than the trans-conformer, suggesting that this class of molecule could be optimised for photo-dynamic therapy applications against infectious pathogens.

Original languageEnglish
Pages (from-to)8067-8070
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume13
Issue number29
Early online date2 Jul 2015
DOIs
Publication statusPublished - 7 Aug 2015

Keywords

  • phospholipid liposomes
  • infectious pathogens
  • azobenzene

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