Functional correlates of positional and gender-specific renal asymmetry in Drosophila

Venkateswara R Chintapalli; Selim Terhzaz; Jing Wang; Mohammed Al Bratty; David G Watson; Pawel Herzyk; Shireen A Davies; Julian A T Dow

doi:10.1371/journal.pone.0032577

Functional correlates of positional and gender-specific renal asymmetry in Drosophila

Venkateswara R Chintapalli, Selim Terhzaz, Jing Wang, Mohammed Al Bratty, David G Watson, Pawel Herzyk, Shireen A Davies, Julian A T Dow

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

80 Downloads (Pure)

Abstract

In humans and other animals, the internal organs are positioned asymmetrically in the body cavity, and disruption of this body plan can be fatal in humans. The mechanisms by which internal asymmetry are established are presently the subject of intense study; however, the functional significance of internal asymmetry (outside the brain) is largely unexplored. Is internal asymmetry functionally significant, or merely an expedient way of packing organs into a cavity?

Original language	English
Pages (from-to)	e32577
Journal	PLOS One
Volume	7
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0032577
Publication status	Published - 4 Apr 2012

Keywords

Drosophila
renal asymmetry
malpighian tubules
developmental genes
neuropeptide-F

Access to Document

10.1371/journal.pone.0032577

Chintapalli-etal-PLoSOne2012Final published version, 694 KBLicence: CC BY 4.0

Cite this

@article{cca69b33ca18409ca64fbddb4cc0e870,

title = "Functional correlates of positional and gender-specific renal asymmetry in Drosophila",

abstract = "In humans and other animals, the internal organs are positioned asymmetrically in the body cavity, and disruption of this body plan can be fatal in humans. The mechanisms by which internal asymmetry are established are presently the subject of intense study; however, the functional significance of internal asymmetry (outside the brain) is largely unexplored. Is internal asymmetry functionally significant, or merely an expedient way of packing organs into a cavity?",

keywords = "Drosophila, renal asymmetry, malpighian tubules, developmental genes, neuropeptide-F",

author = "Chintapalli, {Venkateswara R} and Selim Terhzaz and Jing Wang and {Al Bratty}, Mohammed and Watson, {David G} and Pawel Herzyk and Davies, {Shireen A} and Dow, {Julian A T}",

year = "2012",

month = apr,

day = "4",

doi = "10.1371/journal.pone.0032577",

language = "English",

volume = "7",

pages = "e32577",

journal = "PLOS One",

number = "4",

}

TY - JOUR

T1 - Functional correlates of positional and gender-specific renal asymmetry in Drosophila

AU - Chintapalli, Venkateswara R

AU - Terhzaz, Selim

AU - Wang, Jing

AU - Al Bratty, Mohammed

AU - Watson, David G

AU - Herzyk, Pawel

AU - Davies, Shireen A

AU - Dow, Julian A T

PY - 2012/4/4

Y1 - 2012/4/4

N2 - In humans and other animals, the internal organs are positioned asymmetrically in the body cavity, and disruption of this body plan can be fatal in humans. The mechanisms by which internal asymmetry are established are presently the subject of intense study; however, the functional significance of internal asymmetry (outside the brain) is largely unexplored. Is internal asymmetry functionally significant, or merely an expedient way of packing organs into a cavity?

AB - In humans and other animals, the internal organs are positioned asymmetrically in the body cavity, and disruption of this body plan can be fatal in humans. The mechanisms by which internal asymmetry are established are presently the subject of intense study; however, the functional significance of internal asymmetry (outside the brain) is largely unexplored. Is internal asymmetry functionally significant, or merely an expedient way of packing organs into a cavity?

KW - Drosophila

KW - renal asymmetry

KW - malpighian tubules

KW - developmental genes

KW - neuropeptide-F

UR - http://www.scopus.com/inward/record.url?scp=84859347933&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0032577

DO - 10.1371/journal.pone.0032577

M3 - Article

C2 - 22496733

VL - 7

SP - e32577

JO - PLOS One

JF - PLOS One

IS - 4

ER -

Functional correlates of positional and gender-specific renal asymmetry in Drosophila

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this