Functional brain connectivity phenotypes for schizophrenia drug discovery

Neil Dawson, Brian J Morris, Judith A Pratt

Research output: Contribution to journalArticle

18 Citations (Scopus)
71 Downloads (Pure)

Abstract

While our knowledge of the pathophysiology of schizophrenia has increased dramatically, this has not translated into the development of new and improved drugs to treat this disorder. Human brain imaging and electrophysiological studies have provided dramatic new insight into the mechanisms of brain dysfunction in the disease, with a swathe of recent studies highlighting the differences in functional brain network and neural system connectivity present in the disorder. Only recently has the value of applying these approaches in preclinical rodent models relevant to the disorder started to be recognised. Here we highlight recent findings of altered functional brain connectivity in preclinical rodent models and consider their relevance to those alterations seen in the brains of schizophrenia patients. Furthermore, we highlight the potential translational value of using the paradigm of functional brain connectivity phenotypes in the context of preclinical schizophrenia drug discovery, as a means both to understand the mechanisms of brain dysfunction in the disorder and to reduce the current high attrition rate in schizophrenia drug discovery.

Original languageEnglish
Pages (from-to)169-177
Number of pages9
JournalJournal of Psychopharmacology
Volume29
Issue number2
Early online date7 Jan 2015
DOIs
Publication statusPublished - 1 Feb 2015

Keywords

  • EEG
  • fMRI
  • default mode network
  • graph theory
  • genetic risk factors
  • hippocampal-prefrontal connectivity
  • thalamic connectivity
  • drug discovery

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