Fully automated synthesis of DNA-binding Py-Im polyamides using a triphosgene coupling strategy

Lijing Fang, Guiyang Yao, Zhengyin Pan, Chunlei Wu, Heng-Shan Wang, Glenn A. Burley, Wu Su

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)
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Abstract

The fully automated solid-phase synthetic strategy of hairpin pyrrole−imidazole polyamides is described. A key advance is the development of methodology for the application of triphosgene as a coupling agent in the automated synthesis of hairpin polyamides without racemization. This automated methodology is compatible with all the typical building blocks, enabling the facile synthesis of polyamide libraries in good yield (9−15%) and crude purity.
Original languageEnglish
Pages (from-to)158-161
Number of pages4
JournalOrganic Letters
Volume17
Issue number1
Early online date12 Dec 2014
DOIs
Publication statusPublished - 2 Jan 2015

Keywords

  • hairpin pyrrole–imidazole polyamides
  • DNA binding
  • hairpin polyamide

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