From selection to caged aptamers: identification of light-dependent ssdna aptamers targeting cytohesin

G. Mayer, A. Lohberger, S. Butzen, M. Pofahl, M. Blind, A. Heckel

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Caged aptamers represent valuable tools for the spatiotemporal control of protein function by light. Here we describe a general route starting with the de novo selection process targeting cytohesin-1 and aiming at the synthesis of caged aptamers without the prior knowledge of detailed structural determinants of aptamer-target binding.
Original languageEnglish
Pages (from-to)6561-6564
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number23
DOIs
Publication statusPublished - 1 Dec 2009

Keywords

  • nucleic acids
  • aptamers
  • caged compounds

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