From selection to caged aptamers: identification of light-dependent ssdna aptamers targeting cytohesin

G. Mayer; A. Lohberger; S. Butzen; M. Pofahl; M. Blind; A. Heckel

doi:10.1016/j.bmcl.2009.10.032

From selection to caged aptamers: identification of light-dependent ssdna aptamers targeting cytohesin

G. Mayer, A. Lohberger, S. Butzen, M. Pofahl, M. Blind, A. Heckel

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Caged aptamers represent valuable tools for the spatiotemporal control of protein function by light. Here we describe a general route starting with the de novo selection process targeting cytohesin-1 and aiming at the synthesis of caged aptamers without the prior knowledge of detailed structural determinants of aptamer-target binding.

Original language	English
Pages (from-to)	6561-6564
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	23
DOIs	https://doi.org/10.1016/j.bmcl.2009.10.032
Publication status	Published - 1 Dec 2009

Keywords

nucleic acids
aptamers
caged compounds

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10.1016/j.bmcl.2009.10.032

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title = "From selection to caged aptamers: identification of light-dependent ssdna aptamers targeting cytohesin",

abstract = "Caged aptamers represent valuable tools for the spatiotemporal control of protein function by light. Here we describe a general route starting with the de novo selection process targeting cytohesin-1 and aiming at the synthesis of caged aptamers without the prior knowledge of detailed structural determinants of aptamer-target binding.",

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AU - Mayer, G.

AU - Lohberger, A.

AU - Butzen, S.

AU - Pofahl, M.

AU - Blind, M.

AU - Heckel, A.

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Caged aptamers represent valuable tools for the spatiotemporal control of protein function by light. Here we describe a general route starting with the de novo selection process targeting cytohesin-1 and aiming at the synthesis of caged aptamers without the prior knowledge of detailed structural determinants of aptamer-target binding.

AB - Caged aptamers represent valuable tools for the spatiotemporal control of protein function by light. Here we describe a general route starting with the de novo selection process targeting cytohesin-1 and aiming at the synthesis of caged aptamers without the prior knowledge of detailed structural determinants of aptamer-target binding.

KW - nucleic acids

KW - aptamers

KW - caged compounds

UR - http://dx.doi.org/10.1016/j.bmcl.2009.10.032

U2 - 10.1016/j.bmcl.2009.10.032

DO - 10.1016/j.bmcl.2009.10.032

M3 - Article

VL - 19

SP - 6561

EP - 6564

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 23

ER -

From selection to caged aptamers: identification of light-dependent ssdna aptamers targeting cytohesin

Abstract

Keywords

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