TY - JOUR
T1 - From membrane to skin
T2 - aqueous permeation control through light-responsive amphiphilic polymer co-networks
AU - Schöller, Katrin
AU - Küpfer, Sabrina
AU - Baumann, Lukas
AU - Hoyer, Patrick M.
AU - De Courten, Damien
AU - Rossi, René M.
AU - Vetushka, Aliaksei
AU - Wolf, Martin
AU - Bruns, Nico
AU - Scherer, Lukas J.
PY - 2014/9/3
Y1 - 2014/9/3
N2 - The functionalization of amphiphilic polymer co-networks with light-responsive spiropyran and spirooxazine derivatives leads to a new type of light-responsive materials. The material consisting of hydrophilic nanochannels shows desirable properties such as light-responsive permeability changes of aqueous caffeine solutions, an exceptional repeatability of the photochromism, and tunable basic permeability rates. The versatility of the system is demonstrated by using different functionalization routes such as copolymerization of light-responsive monomers or crosslinker as well as postmodification of the preformed amphiphilic network. Moreover, light-responsive spirobenzopyran and novel spirooxazine derivatives are synthesized, which changes the properties of the light-responsive membranes after inclusion into the amphiphilic co-networks. Finally, the permeability of the delivery membrane can be tailored to match the properties of porcine skin, an in vitro model of human neonatal skin. One possible application might be the use of the light-responsive membranes as key-unit of a transdermal caffeine-delivery system for preterm neonates.
AB - The functionalization of amphiphilic polymer co-networks with light-responsive spiropyran and spirooxazine derivatives leads to a new type of light-responsive materials. The material consisting of hydrophilic nanochannels shows desirable properties such as light-responsive permeability changes of aqueous caffeine solutions, an exceptional repeatability of the photochromism, and tunable basic permeability rates. The versatility of the system is demonstrated by using different functionalization routes such as copolymerization of light-responsive monomers or crosslinker as well as postmodification of the preformed amphiphilic network. Moreover, light-responsive spirobenzopyran and novel spirooxazine derivatives are synthesized, which changes the properties of the light-responsive membranes after inclusion into the amphiphilic co-networks. Finally, the permeability of the delivery membrane can be tailored to match the properties of porcine skin, an in vitro model of human neonatal skin. One possible application might be the use of the light-responsive membranes as key-unit of a transdermal caffeine-delivery system for preterm neonates.
KW - amphiphilic structures
KW - drug delivery
KW - optically active polymers
KW - stimuli-responsive hydrogels
UR - http://www.scopus.com/inward/record.url?scp=84906949525&partnerID=8YFLogxK
U2 - 10.1002/adfm.201400671
DO - 10.1002/adfm.201400671
M3 - Article
AN - SCOPUS:84906949525
SN - 1616-301X
VL - 24
SP - 5194
EP - 5201
JO - Advanced Functional Materials
JF - Advanced Functional Materials
IS - 33
ER -