From emulsion to single-phase microfluidics: an integrated approach to culture and perfusion of multicellular spheroids

Kay S McMillan; Marie Boyd; Michele Zagnoni

From emulsion to single-phase microfluidics: an integrated approach to culture and perfusion of multicellular spheroids

Kay S McMillan, Marie Boyd, Michele Zagnoni

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

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Abstract

This study presents a novel microfluidic approach for developing large scale screening assays of anticancer compounds on 3D multicellular spheroids. We have developed a microfluidic device with associated protocols that combine the high-throughput characteristics of droplet microfluidics for spheroid formation and aggregation with those of single-phase microfluidics for substance exchange, long term culture and drug perfusion.

Original language	English
Title of host publication	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016)
Place of Publication	San Diego, CA
Pages	399-400
Number of pages	2
Publication status	Published - 9 Oct 2016
Event	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Convention Center Dublin, Dublin, Ireland Duration: 9 Oct 2016 → 13 Oct 2016 http://www.microtas2016.org/

Conference

Conference	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Abbreviated title	MicroTas 2016
Country/Territory	Ireland
City	Dublin
Period	9/10/16 → 13/10/16
Internet address	http://www.microtas2016.org/

Keywords

droplet microfluidics
spheroids
cancer
3D cell culture

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McMillan-etal-MicroTas2016-From-emulsion-to-single-phase-microfluidicsAccepted author manuscript, 442 KB

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title = "From emulsion to single-phase microfluidics: an integrated approach to culture and perfusion of multicellular spheroids",

abstract = "This study presents a novel microfluidic approach for developing large scale screening assays of anticancer compounds on 3D multicellular spheroids. We have developed a microfluidic device with associated protocols that combine the high-throughput characteristics of droplet microfluidics for spheroid formation and aggregation with those of single-phase microfluidics for substance exchange, long term culture and drug perfusion.",

keywords = "droplet microfluidics, spheroids, cancer, 3D cell culture",

author = "McMillan, {Kay S} and Marie Boyd and Michele Zagnoni",

year = "2016",

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day = "9",

language = "English",

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pages = "399--400",

booktitle = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016)",

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McMillan, KS, Boyd, M & Zagnoni, M 2016, From emulsion to single-phase microfluidics: an integrated approach to culture and perfusion of multicellular spheroids. in 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). San Diego, CA, pp. 399-400, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Dublin, Ireland, 9/10/16.

From emulsion to single-phase microfluidics: an integrated approach to culture and perfusion of multicellular spheroids. / McMillan, Kay S; Boyd, Marie ; Zagnoni, Michele.
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). San Diego, CA, 2016. p. 399-400.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

TY - GEN

T1 - From emulsion to single-phase microfluidics

T2 - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences

AU - McMillan, Kay S

AU - Boyd, Marie

AU - Zagnoni, Michele

PY - 2016/10/9

Y1 - 2016/10/9

N2 - This study presents a novel microfluidic approach for developing large scale screening assays of anticancer compounds on 3D multicellular spheroids. We have developed a microfluidic device with associated protocols that combine the high-throughput characteristics of droplet microfluidics for spheroid formation and aggregation with those of single-phase microfluidics for substance exchange, long term culture and drug perfusion.

AB - This study presents a novel microfluidic approach for developing large scale screening assays of anticancer compounds on 3D multicellular spheroids. We have developed a microfluidic device with associated protocols that combine the high-throughput characteristics of droplet microfluidics for spheroid formation and aggregation with those of single-phase microfluidics for substance exchange, long term culture and drug perfusion.

KW - droplet microfluidics

KW - spheroids

KW - cancer

KW - 3D cell culture

UR - https://cbmsociety.org/conferences/

UR - http://microtas2016.org

M3 - Conference contribution book

SN - 9781510834163

SP - 399

EP - 400

BT - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016)

CY - San Diego, CA

Y2 - 9 October 2016 through 13 October 2016

ER -

From emulsion to single-phase microfluidics: an integrated approach to culture and perfusion of multicellular spheroids

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