Four new bioactive polybrominated diphenyl ethers of the sponge Dysidea herbacea from West Sumatra, Indonesia

D Handayani, Ruangelie Edrada-Ebel, P Proksch, V Wray, L Witte, R W Van Soest, A Kunzmann, [No Value] Soedarsono

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Abstract

The marine sponge Dysidea herbacea collected from Indonesia yielded four new polybrominated diphenyl ether congeners 2-5 and the known derivatives 1, 6, and 7. The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, 1H-detected direct and long-range 13C-1H correlations) and mass spectrometric (EIMS) data. All of the compounds were active against the Gram-positive bacteria Bacillus subtilis and the phytopathogenic fungus Cladosporium cucumerinum. The isolated polybrominated compounds were also active in the brine shrimp lethality test. In the latter bioassay, compounds 1 and 6 were the most active with LC50's of 0.96 [SE +/- 0.19] and 0.94 [SE +/- 0.70] microg/mL, respectively.

Original languageEnglish
Pages (from-to)1313-1316
Number of pages4
JournalJournal of Natural Products
Volume60
Issue number12
DOIs
Publication statusPublished - Dec 1997

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Keywords

  • animals
  • artemia
  • bacillus subtilis
  • cladosporium
  • drug screening assays, antitumor
  • lethal dose 50
  • magnetic resonance spectroscopy
  • polybrominated biphenyls
  • porifera

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