Four new bioactive lobane diterpenes of the soft coral Lobophytum pauciflorum from Mindoro, Philippines

Ruangelie Edrada-Ebel, P Proksch, V Wray, L Witte, L van Ofwegen

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The marine soft coral Lobophytum pauciflorum collected from Mindoro Island, Philippines, yielded four new lobane diterpene derivatives: the acetate congeners of epoxylobatrienol and lobatrienediol (2 and 7, respectively), a methoxyl congener of lobatetraene (10), and an oxepin congener of lobatrienetriol (11), and six known derivatives (1, 3-6, and 8). The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, 1H-detected direct, and long-range 13C-1H correlations) and mass spectrometric (EIMS) data. All of the compounds were active against the phytopathogenic fungus Cladosporium cucumerinum. Compound 1 was found to be active against the Gram-positive bacteria Bacillus subtilis and the yeast Saccharomyces cerevisiae. The isolated lobane diterpenes were also active in the brine shrimp lethality test. In the latter bioassay, compounds 8 and 10 were the most active congeners with LC50's of 0.64 and 4.18 micrograms/mL, respectively.

Original languageEnglish
Pages (from-to)358-361
Number of pages4
JournalJournal of Natural Products
Volume61
Issue number3
Early online date4 Mar 1998
DOIs
Publication statusPublished - Mar 1998

Keywords

  • animals
  • anti-bacterial agents
  • anti-infective agents
  • antineoplastic agents
  • artemia
  • bacteria
  • cnidaria
  • diterpenes
  • drug screening assays, antitumor
  • fungi
  • magnetic resonance spectroscopy
  • microbial sensitivity tests
  • philippines

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