Abstract
The marine soft coral Lobophytum pauciflorum collected from Mindoro Island, Philippines, yielded four new lobane diterpene derivatives: the acetate congeners of epoxylobatrienol and lobatrienediol (2 and 7, respectively), a methoxyl congener of lobatetraene (10), and an oxepin congener of lobatrienetriol (11), and six known derivatives (1, 3-6, and 8). The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, 1H-detected direct, and long-range 13C-1H correlations) and mass spectrometric (EIMS) data. All of the compounds were active against the phytopathogenic fungus Cladosporium cucumerinum. Compound 1 was found to be active against the Gram-positive bacteria Bacillus subtilis and the yeast Saccharomyces cerevisiae. The isolated lobane diterpenes were also active in the brine shrimp lethality test. In the latter bioassay, compounds 8 and 10 were the most active congeners with LC50's of 0.64 and 4.18 micrograms/mL, respectively.
Original language | English |
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Pages (from-to) | 358-361 |
Number of pages | 4 |
Journal | Journal of Natural Products |
Volume | 61 |
Issue number | 3 |
Early online date | 4 Mar 1998 |
DOIs | |
Publication status | Published - Mar 1998 |
Keywords
- animals
- anti-bacterial agents
- anti-infective agents
- antineoplastic agents
- artemia
- bacteria
- cnidaria
- diterpenes
- drug screening assays, antitumor
- fungi
- magnetic resonance spectroscopy
- microbial sensitivity tests
- philippines