Formulation and development of a validated UV-spectrophotometric analytical method of Rutin tablet

Murad N Abualhasan, Jumana Mansour, Nidal Jaradat, Abdel Naser Zaid, Ibrahim Khadra

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Abstract

Rutin is available in some foods, fruits, and vegetables. It has various beneficial medical effects making it useful in the treatment of various diseases. Rutin is available in different oral dosage forms such as tablets or capsules, widely available in the market. Rutin and many herbal medicines lack quality control due to unavailability of analytical methods. In this study, we formulated rutin tablet and studied its stability using a simple developed analytical method. The dissolution profile of our formulated tablet was also inspected. The results showed that our developed method was linear (R(2) = 0.999), precise (% RSD = 0.026), and accurate (% recovery = 98.55-103.34). The formulated rutin tablet was stable under accelerated conditions as well as room temperature for 150 days (% assay > 91.69). The dissolution profile over 45 minutes of our formulated tablet showed a better dissolution (26.5%) compared with the internationally marketed Rutin® tablet (18.5%). This study can serve as a guideline to companies that manufacture herbal products to improve their formulated herbs and apply validated analytical methods to check the quality of their product.

Original languageEnglish
Article number2624947
Number of pages7
JournalInternational Scholarly Research Notices
Volume2017
DOIs
Publication statusPublished - 16 May 2017

Keywords

  • Rutin
  • disease treatment
  • drug delivery systems

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