Formation of artificial lipid bilayers using droplet dielectrophoresis

Sara Aghdaei, M.E. Sandison, Michele Zagnoni, Nicolas G. Green, Hywel Morgan

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

We describe the formation of artificial bilayer lipid membranes (BLMs) by the controlled, electrical manipulation of aqueous droplets immersed in a lipid–alkane solution. Droplet movement was generated using dielectrophoresis on planar microelectrodes covered in a thin insulator. Droplets, surrounded by lipid monolayers, were brought into contact and spontaneously formed a BLM. The method produced BLMs suitable for single-channel recording of membrane protein activity and the technique can be extended to create programmable BLM arrays and networks.
Original languageEnglish
Pages (from-to)1617–1620
Number of pages5
JournalLab on a Chip
Volume8
Issue number10
Early online date13 Aug 2008
DOIs
Publication statusPublished - Oct 2008

Keywords

  • droplet movement
  • artificial lipid bilayers
  • lipid bilayers
  • droplets

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