The cedrene carbon skeleton was rapidly assembled from a simple monocyclic precursor by the strategic use of a high yielding intramolecular Khand cyclization reaction. Further synthetic manipulations provided a concise formal total synthesis of α- and β-cedrene.
- monocyclic precursor
- Khand cyclization reaction
Kerr, W. J., McLaughlin, M., Morrison, A. J., & Pauson, P. L. (2001). Formal total synthesis of (+/-)-alpha- and beta-cedrene by preparation of cedrone. construction of the tricyclic carbon skeleton by the use of a highly efficient intramolecular khand annulation. Organic Letters, 3(19), 2945-2948. https://doi.org/10.1021/ol016054a