Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements

K. Kokurewicz, E. Brunetti, G. H. Welsh, S. M. Wiggins, M. Boyd, A. Sorensen, A. J. Chalmers, G. Schettino, A. Subiel, C. DesRosiers, D. A. Jaroszynski

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The increased inertia of very high-energy electrons (VHEEs) due to relativistic effects reduces scattering and enables irradiation of deep-seated tumours. However, entrance and exit doses are high for collimated or diverging beams. Here, we perform a study based on Monte Carlo simulations of focused VHEE beams in a water phantom, showing that dose can be concentrated into a small, well-defined volumetric element, which can be shaped or scanned to treat deep-seated tumours. The dose to surrounding tissue is distributed over a larger volume, which reduces peak surface and exit doses for a single beam by more than one order of magnitude compared with a collimated beam.
LanguageEnglish
Article number10837
Number of pages10
JournalScientific Reports
Volume9
DOIs
Publication statusPublished - 25 Jul 2019

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high energy electrons
radiation therapy
electron beams
dosage
tumors
relativistic effects
inertia
entrances
irradiation
scattering
water
simulation

Keywords

  • very high-energy electrons (VHEEs)
  • relativistic effects
  • Monte Carlo simulations
  • deep-seated tumours
  • dose

Cite this

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title = "Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements",
abstract = "The increased inertia of very high-energy electrons (VHEEs) due to relativistic effects reduces scattering and enables irradiation of deep-seated tumours. However, entrance and exit doses are high for collimated or diverging beams. Here, we perform a study based on Monte Carlo simulations of focused VHEE beams in a water phantom, showing that dose can be concentrated into a small, well-defined volumetric element, which can be shaped or scanned to treat deep-seated tumours. The dose to surrounding tissue is distributed over a larger volume, which reduces peak surface and exit doses for a single beam by more than one order of magnitude compared with a collimated beam.",
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Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements. / Kokurewicz, K.; Brunetti, E.; Welsh, G. H.; Wiggins, S. M.; Boyd, M.; Sorensen, A.; Chalmers, A. J.; Schettino, G.; Subiel, A.; DesRosiers, C.; Jaroszynski, D. A.

In: Scientific Reports, Vol. 9, 10837, 25.07.2019.

Research output: Contribution to journalArticle

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T1 - Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements

AU - Kokurewicz, K.

AU - Brunetti, E.

AU - Welsh, G. H.

AU - Wiggins, S. M.

AU - Boyd, M.

AU - Sorensen, A.

AU - Chalmers, A. J.

AU - Schettino, G.

AU - Subiel, A.

AU - DesRosiers, C.

AU - Jaroszynski, D. A.

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KW - very high-energy electrons (VHEEs)

KW - relativistic effects

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