Fmoc-diphenylalanine self assembles to a hydrogel via a novel architecture based on π–π interlocked β-sheets

Andrew Smith, Richard Williams, Claire Tang, Paolo Coppo, Richard Collins, Michael Turner, Alberto Saiani, Rein Vincent Ulijn

Research output: Contribution to journalArticle

563 Citations (Scopus)

Abstract

The self assembly of peptide hydrogelators that carry aromatic substituents can be modeled by a novel nanocylindrical architecture. The proposed model suggests that the nanocylinders are formed by anti-parallel β-sheets interlocked by the π-stacking interactions of fluorenyl groups and phenyl rings. This explanation is consistent with the structures observed in TEM and the data obtained by a variety of spectroscopic techniques.
LanguageEnglish
Pages37-41
Number of pages5
JournalAdvanced Materials
Volume20
Issue number1
Early online date11 Dec 2007
DOIs
Publication statusPublished - 1 Jan 2008

Fingerprint

Hydrogel
Hydrogels
Self assembly
Peptides
Transmission electron microscopy
diphenylalanine

Keywords

  • biomaterials
  • hydrogels
  • peptides

Cite this

Smith, Andrew ; Williams, Richard ; Tang, Claire ; Coppo, Paolo ; Collins, Richard ; Turner, Michael ; Saiani, Alberto ; Ulijn, Rein Vincent. / Fmoc-diphenylalanine self assembles to a hydrogel via a novel architecture based on π–π interlocked β-sheets. In: Advanced Materials. 2008 ; Vol. 20, No. 1. pp. 37-41.
@article{da6ff6841cfe488986bb352eaaca5426,
title = "Fmoc-diphenylalanine self assembles to a hydrogel via a novel architecture based on π–π interlocked β-sheets",
abstract = "The self assembly of peptide hydrogelators that carry aromatic substituents can be modeled by a novel nanocylindrical architecture. The proposed model suggests that the nanocylinders are formed by anti-parallel β-sheets interlocked by the π-stacking interactions of fluorenyl groups and phenyl rings. This explanation is consistent with the structures observed in TEM and the data obtained by a variety of spectroscopic techniques.",
keywords = "biomaterials, hydrogels, peptides",
author = "Andrew Smith and Richard Williams and Claire Tang and Paolo Coppo and Richard Collins and Michael Turner and Alberto Saiani and Ulijn, {Rein Vincent}",
year = "2008",
month = "1",
day = "1",
doi = "10.1002/adma.200701221",
language = "English",
volume = "20",
pages = "37--41",
journal = "Advanced Materials",
issn = "1521-4095",
number = "1",

}

Fmoc-diphenylalanine self assembles to a hydrogel via a novel architecture based on π–π interlocked β-sheets. / Smith, Andrew; Williams, Richard; Tang, Claire; Coppo, Paolo; Collins, Richard; Turner, Michael; Saiani, Alberto; Ulijn, Rein Vincent.

In: Advanced Materials, Vol. 20, No. 1, 01.01.2008, p. 37-41.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Fmoc-diphenylalanine self assembles to a hydrogel via a novel architecture based on π–π interlocked β-sheets

AU - Smith, Andrew

AU - Williams, Richard

AU - Tang, Claire

AU - Coppo, Paolo

AU - Collins, Richard

AU - Turner, Michael

AU - Saiani, Alberto

AU - Ulijn, Rein Vincent

PY - 2008/1/1

Y1 - 2008/1/1

N2 - The self assembly of peptide hydrogelators that carry aromatic substituents can be modeled by a novel nanocylindrical architecture. The proposed model suggests that the nanocylinders are formed by anti-parallel β-sheets interlocked by the π-stacking interactions of fluorenyl groups and phenyl rings. This explanation is consistent with the structures observed in TEM and the data obtained by a variety of spectroscopic techniques.

AB - The self assembly of peptide hydrogelators that carry aromatic substituents can be modeled by a novel nanocylindrical architecture. The proposed model suggests that the nanocylinders are formed by anti-parallel β-sheets interlocked by the π-stacking interactions of fluorenyl groups and phenyl rings. This explanation is consistent with the structures observed in TEM and the data obtained by a variety of spectroscopic techniques.

KW - biomaterials

KW - hydrogels

KW - peptides

U2 - 10.1002/adma.200701221

DO - 10.1002/adma.200701221

M3 - Article

VL - 20

SP - 37

EP - 41

JO - Advanced Materials

T2 - Advanced Materials

JF - Advanced Materials

SN - 1521-4095

IS - 1

ER -