Fmoc-diphenylalanine self assembles to a hydrogel via a novel architecture based on π–π interlocked β-sheets

Andrew Smith, Richard Williams, Claire Tang, Paolo Coppo, Richard Collins, Michael Turner, Alberto Saiani, Rein Vincent Ulijn

Research output: Contribution to journalArticle

626 Citations (Scopus)

Abstract

The self assembly of peptide hydrogelators that carry aromatic substituents can be modeled by a novel nanocylindrical architecture. The proposed model suggests that the nanocylinders are formed by anti-parallel β-sheets interlocked by the π-stacking interactions of fluorenyl groups and phenyl rings. This explanation is consistent with the structures observed in TEM and the data obtained by a variety of spectroscopic techniques.
Original languageEnglish
Pages (from-to)37-41
Number of pages5
JournalAdvanced Materials
Volume20
Issue number1
Early online date11 Dec 2007
DOIs
Publication statusPublished - 1 Jan 2008

Keywords

  • biomaterials
  • hydrogels
  • peptides

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