Abstract
Fluoro- and di-fluoro allylic alcohols obtained from HFC-134a and HCFC-133a were transformed through [3,3]-sigmatropic rearrangements into 3-fluoro-4-halo-4-alkenoates with variable substitution at the 2- and 3-positions. Ozonolysis of the haloalkenes afforded the corresponding acyl halides which could be trapped with nucleophiles to afford fluorinated succinic acid derivatives in which the two carboxylic acid groups were differentiated.
| Original language | English |
|---|---|
| Pages (from-to) | 5269-5273 |
| Number of pages | 5 |
| Journal | Tetrahedron Letters |
| Volume | 41 |
| Issue number | 27 |
| DOIs | |
| Publication status | Published - 1 Jul 2000 |
Keywords
- allylic alcohols
- ozonolysis
- haloalkenes
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Brown, S. J., Corr, S., & Percy, J. (2000). Fluorinated succinic acid derivatives from new refrigerants via ozonolysis of haloalkenes. Tetrahedron Letters, 41(27), 5269-5273 . https://doi.org/10.1016/S0040-4039(00)00804-2