Abstract
A new approach to structural sensing, fluorescence resonance energy transfer nanotomography, which interprets fluorescence decay measurement in terms of site density analysis of molecular distributions, has been applied to a glucose sensor based on competitive binding with malachite green labelled dextran to the sugar binding protein concanavalinA labelled with allophycocyanin. Opportunities for structural sensing in clinical medicine are highlighted.
Original language | English |
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Pages (from-to) | N221-N226 |
Journal | Physics in Medicine and Biology |
Volume | 46 |
Issue number | 2001 |
DOIs | |
Publication status | Published - 22 Aug 2001 |
Keywords
- fluorescence nanotomography
- resonance energy transfer
- protein-sugar complex
- nanoscience