Fluorescence intensity- and lifetime-based glucose sensing using glucose/galactose-binding protein

John Pickup, Faaizah Khan, Zheng-Liang Zhi, Jonathan Coulter, David J S Birch

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We review recent progress in our laboratories towards developing in vivo glucose sensors for diabetes that are based on fluorescence labelling of glucose/galactose-binding protein. Measurement strategies have included both monitoring glucose-induced changes in fluorescence resonance energy transfer and labelling with the environmentally sensitive fluorophore, badan. Measuring fluorescence lifetime rather than intensity has particular potential advantages for in vivo sensing. A prototype fiber optic-based glucose sensor using this technology is being tested.
Original languageEnglish
Pages (from-to)62-71
Number of pages10
JournalJournal of Diabetes Science and Technology
Volume7
Issue number1
DOIs
Publication statusPublished - Jan 2013

Keywords

  • diabetes
  • continuous glucose monitoring
  • glucose sensor
  • glucose/galactose binding protein
  • fluorescence

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