Fluid flow and mass transfer modelling in lysozyme ultrafiltration

Vítor Magueijo, Viriato Semião, Maria Norberta De Pinho

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


This work addresses the mass transfer modelling of ternary solutions, water/lysozyme/sodium chloride, in the slit feed channel of a ultrafiltration (UF) cell. Permeation experiments are performed using a laboratory-made UF cellulose acetate membrane, characterised by an hydraulic permeability of 2.05 × 10-11 m/s/Pa and a molecular weight cut-off of 30 kDa. The simulation of the UF operating conditions with recourse to computer fluid dynamics allows the prediction of the selective permeation performance in terms of permeation fluxes and concentration polarization. The predictions of the permeation fluxes based on different mass transport assumptions are compared with experimental ones and a good agreement is obtained. 

Original languageEnglish
Pages (from-to)1716-1726
Number of pages11
JournalInternational Journal of Heat and Mass Transfer
Issue number9
Publication statusPublished - 1 Apr 2005


  • concentration polarization
  • cross diffusion
  • modelling
  • protein
  • ultrafiltration


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