Fluid flow and mass transfer modelling in lysozyme ultrafiltration

Vítor Magueijo, Viriato Semião, Maria Norberta De Pinho

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

This work addresses the mass transfer modelling of ternary solutions, water/lysozyme/sodium chloride, in the slit feed channel of a ultrafiltration (UF) cell. Permeation experiments are performed using a laboratory-made UF cellulose acetate membrane, characterised by an hydraulic permeability of 2.05 × 10-11 m/s/Pa and a molecular weight cut-off of 30 kDa. The simulation of the UF operating conditions with recourse to computer fluid dynamics allows the prediction of the selective permeation performance in terms of permeation fluxes and concentration polarization. The predictions of the permeation fluxes based on different mass transport assumptions are compared with experimental ones and a good agreement is obtained. 

Original languageEnglish
Pages (from-to)1716-1726
Number of pages11
JournalInternational Journal of Heat and Mass Transfer
Volume48
Issue number9
DOIs
Publication statusPublished - 1 Apr 2005

Fingerprint

lysozyme
Ultrafiltration
Muramidase
Permeation
fluid flow
mass transfer
Flow of fluids
Mass transfer
Enzymes
sodium chlorides
fluid dynamics
predictions
cellulose
hydraulics
slits
acetates
molecular weight
permeability
cut-off
Fluxes

Keywords

  • concentration polarization
  • cross diffusion
  • modelling
  • protein
  • ultrafiltration

Cite this

Magueijo, Vítor ; Semião, Viriato ; De Pinho, Maria Norberta. / Fluid flow and mass transfer modelling in lysozyme ultrafiltration. In: International Journal of Heat and Mass Transfer. 2005 ; Vol. 48, No. 9. pp. 1716-1726.
@article{386a65df6c9d45b889a3c79dc5bd452c,
title = "Fluid flow and mass transfer modelling in lysozyme ultrafiltration",
abstract = "This work addresses the mass transfer modelling of ternary solutions, water/lysozyme/sodium chloride, in the slit feed channel of a ultrafiltration (UF) cell. Permeation experiments are performed using a laboratory-made UF cellulose acetate membrane, characterised by an hydraulic permeability of 2.05 × 10-11 m/s/Pa and a molecular weight cut-off of 30 kDa. The simulation of the UF operating conditions with recourse to computer fluid dynamics allows the prediction of the selective permeation performance in terms of permeation fluxes and concentration polarization. The predictions of the permeation fluxes based on different mass transport assumptions are compared with experimental ones and a good agreement is obtained. ",
keywords = "concentration polarization, cross diffusion, modelling, protein, ultrafiltration",
author = "V{\'i}tor Magueijo and Viriato Semi{\~a}o and {De Pinho}, {Maria Norberta}",
year = "2005",
month = "4",
day = "1",
doi = "10.1016/j.ijheatmasstransfer.2004.11.009",
language = "English",
volume = "48",
pages = "1716--1726",
journal = "International Journal of Heat and Mass Transfer",
issn = "0017-9310",
number = "9",

}

Fluid flow and mass transfer modelling in lysozyme ultrafiltration. / Magueijo, Vítor; Semião, Viriato; De Pinho, Maria Norberta.

In: International Journal of Heat and Mass Transfer, Vol. 48, No. 9, 01.04.2005, p. 1716-1726.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Fluid flow and mass transfer modelling in lysozyme ultrafiltration

AU - Magueijo, Vítor

AU - Semião, Viriato

AU - De Pinho, Maria Norberta

PY - 2005/4/1

Y1 - 2005/4/1

N2 - This work addresses the mass transfer modelling of ternary solutions, water/lysozyme/sodium chloride, in the slit feed channel of a ultrafiltration (UF) cell. Permeation experiments are performed using a laboratory-made UF cellulose acetate membrane, characterised by an hydraulic permeability of 2.05 × 10-11 m/s/Pa and a molecular weight cut-off of 30 kDa. The simulation of the UF operating conditions with recourse to computer fluid dynamics allows the prediction of the selective permeation performance in terms of permeation fluxes and concentration polarization. The predictions of the permeation fluxes based on different mass transport assumptions are compared with experimental ones and a good agreement is obtained. 

AB - This work addresses the mass transfer modelling of ternary solutions, water/lysozyme/sodium chloride, in the slit feed channel of a ultrafiltration (UF) cell. Permeation experiments are performed using a laboratory-made UF cellulose acetate membrane, characterised by an hydraulic permeability of 2.05 × 10-11 m/s/Pa and a molecular weight cut-off of 30 kDa. The simulation of the UF operating conditions with recourse to computer fluid dynamics allows the prediction of the selective permeation performance in terms of permeation fluxes and concentration polarization. The predictions of the permeation fluxes based on different mass transport assumptions are compared with experimental ones and a good agreement is obtained. 

KW - concentration polarization

KW - cross diffusion

KW - modelling

KW - protein

KW - ultrafiltration

UR - http://www.scopus.com/inward/record.url?scp=17644394182&partnerID=8YFLogxK

U2 - 10.1016/j.ijheatmasstransfer.2004.11.009

DO - 10.1016/j.ijheatmasstransfer.2004.11.009

M3 - Article

VL - 48

SP - 1716

EP - 1726

JO - International Journal of Heat and Mass Transfer

JF - International Journal of Heat and Mass Transfer

SN - 0017-9310

IS - 9

ER -