Flow simulation of a natural polymer in a syringe-needle delivery device

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Abstract

Neurodegenerative diseases, such as Parkinson's disease, affect a large num- ber of the erderly population and still remain untreated. In recent years, cell therapy has emerged as a promising therapeutic strategy. To increase cell viability, biomaterials are of- ten used as scaffolds and facilitate cell deposition, through injection, to the site of interest. However, fluid forces acting on the cells during injection may lead to their disruption or death. This study aims to develop a novel device for the delivery of a cell-embedded, in situ forming, collagen hydrogel. A preliminary simulation study on constricted channels rep- resenting the syringe was performed to gain insight into the effect of needle diameter and syringe geometry. Straight needles emanating co-axially from syringes of various geome- tries were computationally modelled in the two-dimensional space, using OpenFOAM. The natural collagen solution was modelled as a continuum medium, without cells, and the flow was assumed incompressible, with non-Newtonian fluid constitutive behaviour. The effects of needle diameter and syringe geometry on velocity and shear stresses were examined. The results highlight the importance of geometric characteristics on the design of new cell delivery devices. If cells pass from the syringe barrel to the needle, the pressure drop and the increased velocity could damage them. This is more likely to occur using higher Gauge needles. Further analysis is required including simulations of cells during injection and analysis of their deformation.
Original languageEnglish
Title of host publicationProceedings of the 6th European Conference on Computational Mechanics
Subtitle of host publicationProceedings of the 6th European Conference on Computational Mechanics
EditorsRoger Owen, Rene de Borst, Jason Reese, Chris Pearce
Place of Publication[Barcelona, Spain]
Pages2938-2949
Number of pages12
ISBN (Electronic)9788494731167
Publication statusPublished - 11 Jun 2018
Event6th European Conference on Computational Mechanics and 7th European Conference on Computational Fluid Dynamics 2018 - Glasgow, United Kingdom
Duration: 11 Jun 201815 Jun 2018

Conference

Conference6th European Conference on Computational Mechanics and 7th European Conference on Computational Fluid Dynamics 2018
Abbreviated titleECCM - ECFD 2018
CountryUnited Kingdom
CityGlasgow
Period11/06/1815/06/18

Keywords

  • cell delivery
  • medical devices
  • non-Newtonian fluid flow

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    Cite this

    Syntouka, I. M., Riches, P. E., Busby, G., & Kazakidi, A. (2018). Flow simulation of a natural polymer in a syringe-needle delivery device. In R. Owen, R. de Borst, J. Reese, & C. Pearce (Eds.), Proceedings of the 6th European Conference on Computational Mechanics: Proceedings of the 6th European Conference on Computational Mechanics (pp. 2938-2949). [Barcelona, Spain].