Flow simulation of a natural polymer in a syringe-needle delivery device

Research output: Contribution to conferencePaper

Abstract

Neurodegenerative diseases, such as Parkinson's disease, affect a large num- ber of the erderly population and still remain untreated. In recent years, cell therapy has emerged as a promising therapeutic strategy. To increase cell viability, biomaterials are of- ten used as scaffolds and facilitate cell deposition, through injection, to the site of interest. However, fluid forces acting on the cells during injection may lead to their disruption or death. This study aims to develop a novel device for the delivery of a cell-embedded, in situ forming, collagen hydrogel. A preliminary simulation study on constricted channels rep- resenting the syringe was performed to gain insight into the effect of needle diameter and syringe geometry. Straight needles emanating co-axially from syringes of various geome- tries were computationally modelled in the two-dimensional space, using OpenFOAM. The natural collagen solution was modelled as a continuum medium, without cells, and the flow was assumed incompressible, with non-Newtonian fluid constitutive behaviour. The effects of needle diameter and syringe geometry on velocity and shear stresses were examined. The results highlight the importance of geometric characteristics on the design of new cell delivery devices. If cells pass from the syringe barrel to the needle, the pressure drop and the increased velocity could damage them. This is more likely to occur using higher Gauge needles. Further analysis is required including simulations of cells during injection and analysis of their deformation.

Conference

Conference6th European Conference on Computational Mechanics and 7th European Conference on Computational Fluid Dynamics 2018
Abbreviated titleECCM - ECFD 2018
CountryUnited Kingdom
CityGlasgow
Period11/06/1815/06/18

Fingerprint

Natural polymers
Syringes
Flow simulation
Needles
Collagen
Geometry
Neurodegenerative diseases
Fluids
Hydrogel
Biocompatible Materials
Biomaterials
Hydrogels
Scaffolds
Gages
Pressure drop
Shear stress
Cells

Keywords

  • cell delivery
  • medical devices
  • non-Newtonian fluid flow

Cite this

Syntouka, I. M., Riches, P. E., Busby, G., & Kazakidi, A. (2018). Flow simulation of a natural polymer in a syringe-needle delivery device. 1-12. Paper presented at 6th European Conference on Computational Mechanics and 7th European Conference on Computational Fluid Dynamics 2018, Glasgow, United Kingdom.
Syntouka, Ioanna M. ; Riches, Philip E. ; Busby, Grahame ; Kazakidi, Asimina. / Flow simulation of a natural polymer in a syringe-needle delivery device. Paper presented at 6th European Conference on Computational Mechanics and 7th European Conference on Computational Fluid Dynamics 2018, Glasgow, United Kingdom.12 p.
@conference{1c47b3ced1f44fa5b48fff28439af32e,
title = "Flow simulation of a natural polymer in a syringe-needle delivery device",
abstract = "Neurodegenerative diseases, such as Parkinson's disease, affect a large num- ber of the erderly population and still remain untreated. In recent years, cell therapy has emerged as a promising therapeutic strategy. To increase cell viability, biomaterials are of- ten used as scaffolds and facilitate cell deposition, through injection, to the site of interest. However, fluid forces acting on the cells during injection may lead to their disruption or death. This study aims to develop a novel device for the delivery of a cell-embedded, in situ forming, collagen hydrogel. A preliminary simulation study on constricted channels rep- resenting the syringe was performed to gain insight into the effect of needle diameter and syringe geometry. Straight needles emanating co-axially from syringes of various geome- tries were computationally modelled in the two-dimensional space, using OpenFOAMⓇ. The natural collagen solution was modelled as a continuum medium, without cells, and the flow was assumed incompressible, with non-Newtonian fluid constitutive behaviour. The effects of needle diameter and syringe geometry on velocity and shear stresses were examined. The results highlight the importance of geometric characteristics on the design of new cell delivery devices. If cells pass from the syringe barrel to the needle, the pressure drop and the increased velocity could damage them. This is more likely to occur using higher Gauge needles. Further analysis is required including simulations of cells during injection and analysis of their deformation.",
keywords = "cell delivery, medical devices, non-Newtonian fluid flow",
author = "Syntouka, {Ioanna M.} and Riches, {Philip E.} and Grahame Busby and Asimina Kazakidi",
year = "2018",
month = "6",
day = "11",
language = "English",
pages = "1--12",
note = "6th European Conference on Computational Mechanics and 7th European Conference on Computational Fluid Dynamics 2018, ECCM - ECFD 2018 ; Conference date: 11-06-2018 Through 15-06-2018",

}

Syntouka, IM, Riches, PE, Busby, G & Kazakidi, A 2018, 'Flow simulation of a natural polymer in a syringe-needle delivery device' Paper presented at 6th European Conference on Computational Mechanics and 7th European Conference on Computational Fluid Dynamics 2018, Glasgow, United Kingdom, 11/06/18 - 15/06/18, pp. 1-12.

Flow simulation of a natural polymer in a syringe-needle delivery device. / Syntouka, Ioanna M.; Riches, Philip E.; Busby, Grahame; Kazakidi, Asimina.

2018. 1-12 Paper presented at 6th European Conference on Computational Mechanics and 7th European Conference on Computational Fluid Dynamics 2018, Glasgow, United Kingdom.

Research output: Contribution to conferencePaper

TY - CONF

T1 - Flow simulation of a natural polymer in a syringe-needle delivery device

AU - Syntouka, Ioanna M.

AU - Riches, Philip E.

AU - Busby, Grahame

AU - Kazakidi, Asimina

PY - 2018/6/11

Y1 - 2018/6/11

N2 - Neurodegenerative diseases, such as Parkinson's disease, affect a large num- ber of the erderly population and still remain untreated. In recent years, cell therapy has emerged as a promising therapeutic strategy. To increase cell viability, biomaterials are of- ten used as scaffolds and facilitate cell deposition, through injection, to the site of interest. However, fluid forces acting on the cells during injection may lead to their disruption or death. This study aims to develop a novel device for the delivery of a cell-embedded, in situ forming, collagen hydrogel. A preliminary simulation study on constricted channels rep- resenting the syringe was performed to gain insight into the effect of needle diameter and syringe geometry. Straight needles emanating co-axially from syringes of various geome- tries were computationally modelled in the two-dimensional space, using OpenFOAMⓇ. The natural collagen solution was modelled as a continuum medium, without cells, and the flow was assumed incompressible, with non-Newtonian fluid constitutive behaviour. The effects of needle diameter and syringe geometry on velocity and shear stresses were examined. The results highlight the importance of geometric characteristics on the design of new cell delivery devices. If cells pass from the syringe barrel to the needle, the pressure drop and the increased velocity could damage them. This is more likely to occur using higher Gauge needles. Further analysis is required including simulations of cells during injection and analysis of their deformation.

AB - Neurodegenerative diseases, such as Parkinson's disease, affect a large num- ber of the erderly population and still remain untreated. In recent years, cell therapy has emerged as a promising therapeutic strategy. To increase cell viability, biomaterials are of- ten used as scaffolds and facilitate cell deposition, through injection, to the site of interest. However, fluid forces acting on the cells during injection may lead to their disruption or death. This study aims to develop a novel device for the delivery of a cell-embedded, in situ forming, collagen hydrogel. A preliminary simulation study on constricted channels rep- resenting the syringe was performed to gain insight into the effect of needle diameter and syringe geometry. Straight needles emanating co-axially from syringes of various geome- tries were computationally modelled in the two-dimensional space, using OpenFOAMⓇ. The natural collagen solution was modelled as a continuum medium, without cells, and the flow was assumed incompressible, with non-Newtonian fluid constitutive behaviour. The effects of needle diameter and syringe geometry on velocity and shear stresses were examined. The results highlight the importance of geometric characteristics on the design of new cell delivery devices. If cells pass from the syringe barrel to the needle, the pressure drop and the increased velocity could damage them. This is more likely to occur using higher Gauge needles. Further analysis is required including simulations of cells during injection and analysis of their deformation.

KW - cell delivery

KW - medical devices

KW - non-Newtonian fluid flow

UR - http://www.eccm-ecfd2018.org/frontal/default.asp

UR - http://www.eccm-ecfd2018.org/admin/files/filePaper/p1379.pdf

M3 - Paper

SP - 1

EP - 12

ER -

Syntouka IM, Riches PE, Busby G, Kazakidi A. Flow simulation of a natural polymer in a syringe-needle delivery device. 2018. Paper presented at 6th European Conference on Computational Mechanics and 7th European Conference on Computational Fluid Dynamics 2018, Glasgow, United Kingdom.