Flow simulation of a collagen solution in syringes with different geometries

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Abstract

In recent years, cell therapy has emerged as a promising therapeutic strategy for many diseases, including Parkinson’s disease [1]. To increase cell viability, biomaterials are often used as scaffolds to facilitate cell deposition, through injection, to the site of interest. However, fluid forces acting on the cells during injection may lead to cell disruption or death [2]. This study aims to develop a novel device for the delivery of a cell-embedded collagen hydrogel, forming in situ. Here, we discuss computational results on constricted channels representing the connection between the syringe barrel and the needle to gain insight into the effect of syringe geometry.
Original languageEnglish
Title of host publicationBioMedEng18 Proceedings
Subtitle of host publicationThe UK's largest gathering of Biomedical Engineers, Medical Engineers and Bioengineers
Place of PublicationLondon
Publication statusPublished - 7 Sep 2018
EventBioMedEng18 - Imperial College, London, United Kingdom
Duration: 6 Sep 20187 Sep 2018
https://www.biomedeng18.com/

Conference

ConferenceBioMedEng18
Abbreviated titleBioMedEng
Country/TerritoryUnited Kingdom
CityLondon
Period6/09/187/09/18
Internet address

Keywords

  • cell therapy
  • collagen gel
  • syringe geometry

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