First organophosphorus radical-mediated cyclisations to afford medium-sized rings: eight-membered lactones and seven- and eight-membered lactams

Stuart Lang, Michael Corr, Neil Muir, Tanweer Khan, Franziska Schonebeck, John Murphy, Andrew Payne, Andrew Williams

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The phosphorus based radical precursors N-ethylpiperidine hypophosphite (EPHP) and diethylphosphine oxide (DEPO) are efficient reagents for carrying out the formation of seven- and eight-membered rings. Esters and amides were successfully converted into the corresponding eight-membered lactones and seven- and eight-membered lactams in good to excellent yields.
Original languageEnglish
Pages (from-to)4027-4030
Number of pages3
JournalTetrahedron Letters
Volume46
Issue number23
Early online date22 Apr 2005
DOIs
Publication statusPublished - 2005

Keywords

  • radical
  • phosphorus
  • DEPO
  • EPHP
  • cyclisation

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