Ferritin level: a predictor of severity and mortality in hospitalized COVID-19 patients

Moudhi Alroomi, Rajesh Rajan, Abdulaziz A. Omar, Ahmad Alsaber, Jiazhu Pan, Mina Fatemi, Kobalava D. Zhanna, Wael Aboelhassan, Farah Almutairi, Naser Alotaibi, Mohammad A. Saleh, Noor AlNasrallah, Bader Al-Bader, Haya Malhas, Maryam Ramadhan, Mohammed Abdullah, Hassan Abdelnaby

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Abstract

Introduction: This study aims to investigate in-hоsрitаl mоrtаlity in severe асute resрirаtоry syndrоme соrоnаvirus 2 раtients strаtified by serum ferritin levels. Methods: Patients were stratified based on ferritin levels (ferritin levels ≤ 1000 or >1000). Results: Approximately 89% (118) of the patients with ferritin levels > 1000 had pneumonia, and 51% (67) had hypertension. Fever (97, 73.5%) and shortness of breath (80, 61%) were two major symptoms among the patients in this group. Logistic regression analysis indicated that ferritin level (odds ratio [OR] = 0.36, 95% confidence interval [CI] = 0.21–0.62; p <.001), male sex (OR = 2.63, 95% CI = 1.43–5.06; p =.003), hypertension (OR = 4.16, 95% CI = 2.42–7.36; p <.001) and pneumonia (OR = 8.48, 95% CI = 3.02–35.45; p <.001) had significance in predicting in-hospital mortality. Additionally, the Cox proportional hazards analysis and Kaplan–Meier survival probability plot showed a higher mortality rate among patients with ferritin levels > 1000. Conclusion: In this study, higher levels of serum ferritin were found to be an independent predictor of in-hоsрitаl mоrtаlity.

Original languageEnglish
Number of pages8
JournalImmunity, Inflammation and Disease
Early online date26 Aug 2021
DOIs
Publication statusE-pub ahead of print - 26 Aug 2021

Keywords

  • ferritin
  • COVID-19
  • in-hospital mortality
  • male sex
  • SARS-CoV-2
  • hypertension
  • pneumonia

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