Feeding stimulated by very low doses of d-amphetamine administered systemically or by microinjection into the striatum

Philip Winn, Sarah F. Williams, L. J. Herberg

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Abstract

The effects of d-amphetamine over a wide range of doses (0.125-4.0 mg/kg IP) on rat unconditioned behaviour were examined in the presence of food and water (experiment 1), in their absence (experiment 2) and after microinjection (2.0 μg in 0.5 μl) directly into the striatum (experiment 3). In experiment 1 very low doses (0.125 and 0.25 mg/kg) stimulated the intake of food, but not water, and higher doses produced locomotor hyperactivity, rearing, stereotyped sniffing and anorexia. In experiment 2 all doses, including very low doses (0.125 and 0.25 mg/kg), significantly potentiated locomotor activity. In experiment 3, microinjection into the corpus striatum elicited substantial feeding, but not drinking, locomotor activity or stereotyped behaviour. The results suggest that a single graded facilitative mechanism underlies the effects on food intake and other behavioural effects of amphetamine, as implied by a general hypothesis of amphetamine action proposed in the literature, and that these effects may to a large extent by mediated by forebrain dopamine systems.

Original languageEnglish
Pages (from-to)336-341
Number of pages6
JournalPsychopharmacology
Volume78
Issue number4
DOIs
Publication statusPublished - 31 Dec 1982

Keywords

  • d-Amphetamine
  • feeding
  • locomotion
  • rat
  • stereotypy
  • striatum

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