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A new hardware-friendly bi-exponential fluorescence lifetime imaging (FLIM) algorithm has been proposed. Compared to conventional FLIM software, the proposed algorithms are non-iterative offering direct calculation of lifetimes and therefore suitable for real-time applications. They can be applicable to single-channel or 2D multi-channel time-correlated single-photon counting (TCSPC) systems. The proposed methods have been tested on both synthesized and realistic FLIM data, and we have compared their performances with other recently proposed non-fitting bi-exponential techniques showing promising applications in future massive solid-state TCSPC imagers.
- coherence and statistical optics
- photon counting
- medical optics and biotechnology
- fluorescence lifetime imaging
- time-correlated singlephoton counting
Sefcik, J., Sutter, J. U., Xue, Q., Yu, J., Wang, J., Birch, D. J. S. & Chen, Y., 9 Dec 2015, In: Optics Letters. 40, 24, p. 5738–5741 4 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile3 Citations (Scopus)56 Downloads (Pure)