Projects per year
Abstract
Parasitic helminths and their isolated secreted products show promise as novel treatments for allergic and autoimmune conditions in humans. Foremost amongst the secreted products is ES-62, a glycoprotein derived from Acanthocheilonema viteae, a filarial nematode parasite of gerbils, which is anti-inflammatory by virtue of covalently-attached phosphorylcholine (PC) moieties. ES-62 has been found to protect against disease in mouse models of rheumatoid arthritis, systemic lupus erythematosus, and airway hyper-responsiveness. Furthermore, novel PC-based synthetic small molecule analogues (SMAs) of ES-62 have recently been demonstrated to show similar anti-inflammatory properties to the parent molecule. In spite of these successes, we now show that ES-62 and its SMAs are unable to provide protection in mouse models of certain autoimmune conditions where other helminth species or their secreted products can prevent disease development, namely type I diabetes, multiple sclerosis and inflammatory bowel disease. We speculate on the reasons underlying ES-62’s failures in these conditions and how the negative data generated may help us to further understand ES-62’s mechanism of action.
Original language | English |
---|---|
Article number | 2669 |
Number of pages | 14 |
Journal | Molecules |
Volume | 23 |
Issue number | 10 |
DOIs | |
Publication status | Published - 17 Oct 2018 |
Keywords
- ES-62
- helminth
- inflammatory bowel disease
- multiple sclerosis
- nematode
- type 1 diabetes
Fingerprint
Dive into the research topics of 'Failure of the anti-inflammatory parasitic worm product ES-62 to provide protection in mouse models of type I diabetes, multiple sclerosis, and inflammatory bowel disease'. Together they form a unique fingerprint.Projects
- 2 Finished
-
The Filarial Nematode Immunomodulator Es-62 As A Tool In Novel Drug Development For Mast Cell-Dependent Inflammatory Diseases
Harnett, W. (Principal Investigator)
1/05/09 → 31/08/15
Project: Research
-
SMALL MOLECULE ANALOGUES (SMA'S) OF AN IMMUNOMDULATORY HELMINTH PRODUCT PROVIDE A NOVEL APPROACH TO DISSECTING MACROPHAGE SIGNAL TRANDUCTION PATHWAYS
Harnett, W. (Principal Investigator) & Suckling, C. (Co-investigator)
BBSRC (Biotech & Biological Sciences Research Council)
1/05/07 → 31/12/10
Project: Research