Facile synthesis of Schiff and Mannich bases of isatin derivatives

Ahmed A. H. Al-kadhimi, Nuhad K. E. Al-azzawi, Abedawn I. Khalaf

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We report herein on the synthesis of some isatin Schiff’s bases (1–11), which were prepared from the reaction of isatin and some aromatic amines. These in turn were converted to the corresponding Mannich bases (12-23) by reaction with a number of secondary amines and formaldehyde, taking advantage of the active –NH group in the isatin. The structures of these compounds were elucidated using standard spectroscopic and analytical methods.
Original languageEnglish
Pages (from-to)2338-2349
Number of pages12
JournalJournal of Chemical, Biological and Physical Sciences
Issue number3
Publication statusPublished - May 2015


  • Isatin
  • Isatin Schiff’s
  • Mannich bases


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