Projects per year
Integrin inhibitors based on the tripeptide sequence Arg-Gly-Asp (RGD) are potential therapeutics for the treatment of idiopathic pulmonary fibrosis (IPF). Herein, we describe an expeditious three-step synthetic sequence of Horner-Wadsworth-Emmons olefination, diimide reduction, and global deprotection to synthesise cores for these compounds in high yields (63-83% over 3 steps) with no need for chromatography. Key to this transformation is the phosphoramidate protecting group, which is stable to metalation steps.
|Number of pages||10|
|Journal||Beilstein Journal of Organic Chemistry|
|Publication status||Published - 8 Jul 2020|
FingerprintDive into the research topics of 'Facile synthesis of 7-alkyl-1,2,3,4-tetrahydro-1,8-naphthyridines as arginine mimetics using a Horner-Wadsworth-Emmons-based approach'. Together they form a unique fingerprint.
- 1 Active
PP: Accelerated Discovery and Development of New Medicines: Prosperity Partnership for a Healthier Nation
Murphy, J. & Bell, J.
1/01/19 → 31/12/23