Facile DNA immobilization on surfaces through a catecholamine polymer

H. O. Ham, Z. Q. Liu, K. H. A. Lau, H. Lee, P. B. Messersmith

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

Simple immersion of noble metals, oxides, semiconductors, and synthetic polymer substrates in a mussel-mimetic catecholamine polymer solution p(DOMA-AEMA) leads to formation of a thin film on the substrate. The resulting coated substrates can bind DNA without further surface treatment. This approach provides a new entrance to DNA microarray fabrication.
Original languageEnglish
Pages (from-to)732-736
Number of pages5
JournalAngewandte Chemie International Edition
Volume50
Issue number3
Early online date22 Dec 2010
DOIs
Publication statusPublished - 17 Jan 2011

Keywords

  • fluorescence fabrication strategies
  • biomimetic synthesis
  • biosensors
  • catecholamine DNA
  • immobilization
  • surface modification
  • covalent attachment
  • microarray technology
  • mytilus-edulis
  • gold surfaces
  • glass slides
  • tof-sims
  • oligonucleotides

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