F3-Peptide targeted lipid-based nanoparticles useful for the treatment of angiogenesis-dependent diseases

Joao Nuno Moreira (Inventor), Lígia C Gomes-da-Silva (Inventor), Luis Bimbo (Inventor), Adriana Oliveira Santos (Inventor), Maria C Pedroso de Lima (Inventor), Sérgio Simões (Inventor)

Research output: Patent

Abstract

The present invention relates to F3 -peptide targeted lipid-based nanoparticles, adequate to encapsulate and delivery- one or more nucleic acids, comprising; a) one or more nucleic acids; b) one or more cationic lipids; c) one or more non- cationic lipids; d) one or more poly (ethylene glycol) - derivatized lipids; and e) one or more coupled targeting ligands which bind to the nucleolin receptor. The nanoparticles according to the invention have a high loading capacity, ability to protect the encapsulated nucleic acid, a size below 250 ran and a charge close to neutrality, which are adequate features for intravenous administration. The nanoparticles of the present inventon have the ability to selectively delivery a siRNA to cancer cells and/or endothelial cells from angiogenic blood vessels leading to an effective silencing of a target gene. These nanoparticles are used for the treatment of angiogenesis- dependent diseases, namely cancer, inflammation, an auto-immune disease or an ocular disorder.
Original languageEnglish
Patent numberWO2011119058
IPCA61K9/127
Priority date21/03/13
Publication statusPublished - 29 Sep 2011
Externally publishedYes

Keywords

  • F3-peptide nanoparticles
  • lipid based nanoparticles
  • gene silencing
  • cancer

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