Extracellular actions of sphingosine 1-phosphate through endothelial differentiation gene products in mammalian cells: role in regulating proliferation and apoptosis

S Pyne, S Rakhit, A M Conway, A McKie, P Darroch, R Tate, N Pyne

Research output: Contribution to journalLiterature review

9 Citations (Scopus)

Abstract

Sphingosine 1-phosphate (SIP) belongs to a group of platelet-derived lipid mediators that regulate cell differentiation, survival and proliferation. It is
released from platelets after their activation with agents such as thrombin [l]. In addition, intracellular levels of S1 P are increased in several cell types in response to stimulation by a variety of agonists that include platelet-derived growth factor (PDGF) [2,3], tumour necrosis factor 01 (TNFa), nerve growth factor (NGF), vitamin D,, carbachol (acting at M2 and M3 muscarinic acetylcholine receptors), protein kinases C activators (such as phorbol esters), CAMP elevating agents and the cross-linking of antigen to FcRl or FcyRl receptors. SIP is formed by the phosphorylation
of sphingosine, which is catalysed by sphingosine kinase [4].
Original languageEnglish
Pages (from-to)404-409
Number of pages6
JournalBiochemical Society Transactions
Volume27
Issue number4
DOIs
Publication statusPublished - Aug 1999

Keywords

  • protein-coupled receptors
  • sphingomyelin-derived lipids
  • growth-factor receptor
  • airway smooth muscle
  • beta gamma subunits
  • molecular cloning
  • kinase activation
  • signaling pathways

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