Extracellular actions of sphingosine 1-phosphate through endothelial differentiation gene products in mammalian cells: role in regulating proliferation and apoptosis

S  Pyne; S  Rakhit; A M  Conway; A  McKie; P  Darroch; R  Tate; N  Pyne

doi:10.1042/bst0270404

Extracellular actions of sphingosine 1-phosphate through endothelial differentiation gene products in mammalian cells: role in regulating proliferation and apoptosis

S Pyne, S Rakhit, A M Conway, A McKie, P Darroch, R Tate, N Pyne

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Literature review › peer-review

10 Citations (Scopus)

Abstract

Sphingosine 1-phosphate (SIP) belongs to a group of platelet-derived lipid mediators that regulate cell differentiation, survival and proliferation. It is
released from platelets after their activation with agents such as thrombin [l]. In addition, intracellular levels of S1 P are increased in several cell types in response to stimulation by a variety of agonists that include platelet-derived growth factor (PDGF) [2,3], tumour necrosis factor 01 (TNFa), nerve growth factor (NGF), vitamin D,, carbachol (acting at M2 and M3 muscarinic acetylcholine receptors), protein kinases C activators (such as phorbol esters), CAMP elevating agents and the cross-linking of antigen to FcRl or FcyRl receptors. SIP is formed by the phosphorylation
of sphingosine, which is catalysed by sphingosine kinase [4].

Original language	English
Pages (from-to)	404-409
Number of pages	6
Journal	Biochemical Society Transactions
Volume	27
Issue number	4
DOIs	https://doi.org/10.1042/bst0270404
Publication status	Published - Aug 1999

Keywords

protein-coupled receptors
sphingomyelin-derived lipids
growth-factor receptor
airway smooth muscle
beta gamma subunits
molecular cloning
kinase activation
signaling pathways

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10.1042/bst0270404

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title = "Extracellular actions of sphingosine 1-phosphate through endothelial differentiation gene products in mammalian cells: role in regulating proliferation and apoptosis",

abstract = "Sphingosine 1-phosphate (SIP) belongs to a group of platelet-derived lipid mediators that regulate cell differentiation, survival and proliferation. It isreleased from platelets after their activation with agents such as thrombin [l]. In addition, intracellular levels of S1 P are increased in several cell types in response to stimulation by a variety of agonists that include platelet-derived growth factor (PDGF) [2,3], tumour necrosis factor 01 (TNFa), nerve growth factor (NGF), vitamin D,, carbachol (acting at M2 and M3 muscarinic acetylcholine receptors), protein kinases C activators (such as phorbol esters), CAMP elevating agents and the cross-linking of antigen to FcRl or FcyRl receptors. SIP is formed by the phosphorylationof sphingosine, which is catalysed by sphingosine kinase [4].",

keywords = "protein-coupled receptors, sphingomyelin-derived lipids, growth-factor receptor, airway smooth muscle, beta gamma subunits, molecular cloning, kinase activation, signaling pathways",

author = "S Pyne and S Rakhit and Conway, {A M} and A McKie and P Darroch and R Tate and N Pyne",

year = "1999",

month = aug,

doi = "10.1042/bst0270404",

language = "English",

volume = "27",

pages = "404--409",

journal = "Biochemical Society Transactions",

issn = "0300-5127",

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T1 - Extracellular actions of sphingosine 1-phosphate through endothelial differentiation gene products in mammalian cells: role in regulating proliferation and apoptosis

AU - Pyne, S

AU - Rakhit, S

AU - Conway, A M

AU - McKie, A

AU - Darroch, P

AU - Tate, R

AU - Pyne, N

PY - 1999/8

Y1 - 1999/8

N2 - Sphingosine 1-phosphate (SIP) belongs to a group of platelet-derived lipid mediators that regulate cell differentiation, survival and proliferation. It isreleased from platelets after their activation with agents such as thrombin [l]. In addition, intracellular levels of S1 P are increased in several cell types in response to stimulation by a variety of agonists that include platelet-derived growth factor (PDGF) [2,3], tumour necrosis factor 01 (TNFa), nerve growth factor (NGF), vitamin D,, carbachol (acting at M2 and M3 muscarinic acetylcholine receptors), protein kinases C activators (such as phorbol esters), CAMP elevating agents and the cross-linking of antigen to FcRl or FcyRl receptors. SIP is formed by the phosphorylationof sphingosine, which is catalysed by sphingosine kinase [4].

AB - Sphingosine 1-phosphate (SIP) belongs to a group of platelet-derived lipid mediators that regulate cell differentiation, survival and proliferation. It isreleased from platelets after their activation with agents such as thrombin [l]. In addition, intracellular levels of S1 P are increased in several cell types in response to stimulation by a variety of agonists that include platelet-derived growth factor (PDGF) [2,3], tumour necrosis factor 01 (TNFa), nerve growth factor (NGF), vitamin D,, carbachol (acting at M2 and M3 muscarinic acetylcholine receptors), protein kinases C activators (such as phorbol esters), CAMP elevating agents and the cross-linking of antigen to FcRl or FcyRl receptors. SIP is formed by the phosphorylationof sphingosine, which is catalysed by sphingosine kinase [4].

KW - protein-coupled receptors

KW - sphingomyelin-derived lipids

KW - growth-factor receptor

KW - airway smooth muscle

KW - beta gamma subunits

KW - molecular cloning

KW - kinase activation

KW - signaling pathways

UR - http://www.biochemsoctrans.org/bst/

U2 - 10.1042/bst0270404

DO - 10.1042/bst0270404

M3 - Literature review

SN - 0300-5127

VL - 27

SP - 404

EP - 409

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 4

ER -

Extracellular actions of sphingosine 1-phosphate through endothelial differentiation gene products in mammalian cells: role in regulating proliferation and apoptosis

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Keywords

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