Extracellular actions of sphingosine 1-phosphate through endothelial differentiation gene products in mammalian cells: role in regulating proliferation and apoptosis

S Pyne, S Rakhit, A M Conway, A McKie, P Darroch, R Tate, N Pyne

Research output: Contribution to journalLiterature review

9 Citations (Scopus)

Abstract

Sphingosine 1-phosphate (SIP) belongs to a group of platelet-derived lipid mediators that regulate cell differentiation, survival and proliferation. It is
released from platelets after their activation with agents such as thrombin [l]. In addition, intracellular levels of S1 P are increased in several cell types in response to stimulation by a variety of agonists that include platelet-derived growth factor (PDGF) [2,3], tumour necrosis factor 01 (TNFa), nerve growth factor (NGF), vitamin D,, carbachol (acting at M2 and M3 muscarinic acetylcholine receptors), protein kinases C activators (such as phorbol esters), CAMP elevating agents and the cross-linking of antigen to FcRl or FcyRl receptors. SIP is formed by the phosphorylation
of sphingosine, which is catalysed by sphingosine kinase [4].
LanguageEnglish
Pages404-409
Number of pages6
JournalBiochemical Society Transactions
Volume27
Issue number4
DOIs
Publication statusPublished - Aug 1999

Fingerprint

Platelets
Blood Platelets
Genes
Cells
Apoptosis
Sphingosine
Platelet-Derived Growth Factor
Carbachol
Phorbol Esters
Muscarinic Receptors
Nerve Growth Factor
Vitamin D
Thrombin
Protein Kinase C
Cell Differentiation
Cell Survival
Tumor Necrosis Factor-alpha
Chemical activation
Cell Proliferation
Lipids

Keywords

  • protein-coupled receptors
  • sphingomyelin-derived lipids
  • growth-factor receptor
  • airway smooth muscle
  • beta gamma subunits
  • molecular cloning
  • kinase activation
  • signaling pathways

Cite this

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title = "Extracellular actions of sphingosine 1-phosphate through endothelial differentiation gene products in mammalian cells: role in regulating proliferation and apoptosis",
abstract = "Sphingosine 1-phosphate (SIP) belongs to a group of platelet-derived lipid mediators that regulate cell differentiation, survival and proliferation. It isreleased from platelets after their activation with agents such as thrombin [l]. In addition, intracellular levels of S1 P are increased in several cell types in response to stimulation by a variety of agonists that include platelet-derived growth factor (PDGF) [2,3], tumour necrosis factor 01 (TNFa), nerve growth factor (NGF), vitamin D,, carbachol (acting at M2 and M3 muscarinic acetylcholine receptors), protein kinases C activators (such as phorbol esters), CAMP elevating agents and the cross-linking of antigen to FcRl or FcyRl receptors. SIP is formed by the phosphorylationof sphingosine, which is catalysed by sphingosine kinase [4].",
keywords = "protein-coupled receptors, sphingomyelin-derived lipids, growth-factor receptor, airway smooth muscle, beta gamma subunits, molecular cloning, kinase activation, signaling pathways",
author = "S Pyne and S Rakhit and Conway, {A M} and A McKie and P Darroch and R Tate and N Pyne",
year = "1999",
month = "8",
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language = "English",
volume = "27",
pages = "404--409",
journal = "Biochemical Society Transactions",
issn = "0300-5127",
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Extracellular actions of sphingosine 1-phosphate through endothelial differentiation gene products in mammalian cells: role in regulating proliferation and apoptosis. / Pyne, S ; Rakhit, S ; Conway, A M ; McKie, A ; Darroch, P ; Tate, R ; Pyne, N .

In: Biochemical Society Transactions, Vol. 27, No. 4, 08.1999, p. 404-409.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - Extracellular actions of sphingosine 1-phosphate through endothelial differentiation gene products in mammalian cells: role in regulating proliferation and apoptosis

AU - Pyne, S

AU - Rakhit, S

AU - Conway, A M

AU - McKie, A

AU - Darroch, P

AU - Tate, R

AU - Pyne, N

PY - 1999/8

Y1 - 1999/8

N2 - Sphingosine 1-phosphate (SIP) belongs to a group of platelet-derived lipid mediators that regulate cell differentiation, survival and proliferation. It isreleased from platelets after their activation with agents such as thrombin [l]. In addition, intracellular levels of S1 P are increased in several cell types in response to stimulation by a variety of agonists that include platelet-derived growth factor (PDGF) [2,3], tumour necrosis factor 01 (TNFa), nerve growth factor (NGF), vitamin D,, carbachol (acting at M2 and M3 muscarinic acetylcholine receptors), protein kinases C activators (such as phorbol esters), CAMP elevating agents and the cross-linking of antigen to FcRl or FcyRl receptors. SIP is formed by the phosphorylationof sphingosine, which is catalysed by sphingosine kinase [4].

AB - Sphingosine 1-phosphate (SIP) belongs to a group of platelet-derived lipid mediators that regulate cell differentiation, survival and proliferation. It isreleased from platelets after their activation with agents such as thrombin [l]. In addition, intracellular levels of S1 P are increased in several cell types in response to stimulation by a variety of agonists that include platelet-derived growth factor (PDGF) [2,3], tumour necrosis factor 01 (TNFa), nerve growth factor (NGF), vitamin D,, carbachol (acting at M2 and M3 muscarinic acetylcholine receptors), protein kinases C activators (such as phorbol esters), CAMP elevating agents and the cross-linking of antigen to FcRl or FcyRl receptors. SIP is formed by the phosphorylationof sphingosine, which is catalysed by sphingosine kinase [4].

KW - protein-coupled receptors

KW - sphingomyelin-derived lipids

KW - growth-factor receptor

KW - airway smooth muscle

KW - beta gamma subunits

KW - molecular cloning

KW - kinase activation

KW - signaling pathways

UR - http://www.biochemsoctrans.org/bst/

U2 - 10.1042/bst0270404

DO - 10.1042/bst0270404

M3 - Literature review

VL - 27

SP - 404

EP - 409

JO - Biochemical Society Transactions

T2 - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

IS - 4

ER -