Expression and function of IL-33/ST2 axis in the central nervous system under normal and diseased conditions

Karen Fairlie-Clarke , Mark Barbour, Chelsey Wilson, Shehla U. Hridi, Debbie Allan, Hui-Rong Jiang

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Interleukin-33 (IL-33) is a well-recognised immunomodulatory cytokine which plays critical roles in tissue function and immune-mediated diseases. The abundant expression of IL-33 in brain and spinal cord prompted many scientists to explore its unique role in the central nervous system (CNS) under physiological and pathological conditions. Indeed emerging evidence from over a decade’s research suggests that IL-33 acts as one of the key molecular signalling cues coordinating the network between the immune and CNS systems, particularly during the development of neurological diseases. Here, we highlight the recent advances in our knowledge regarding the distribution and cellular localisation of IL-33 and its receptor ST2 in specific CNS regions, and more importantly the key roles IL-33/ST2 signalling pathway play in CNS function under normal and diseased conditions.
LanguageEnglish
Article number2596
Number of pages16
JournalFrontiers in Immunology
Volume9
DOIs
Publication statusPublished - 20 Nov 2018

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Central Nervous System
Immune System Diseases
Cues
Spinal Cord
Cytokines
Interleukin-33
Brain
Research

Keywords

  • IL-33
  • ST2
  • central nervous system
  • expression
  • neurological diseases

Cite this

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title = "Expression and function of IL-33/ST2 axis in the central nervous system under normal and diseased conditions",
abstract = "Interleukin-33 (IL-33) is a well-recognised immunomodulatory cytokine which plays critical roles in tissue function and immune-mediated diseases. The abundant expression of IL-33 in brain and spinal cord prompted many scientists to explore its unique role in the central nervous system (CNS) under physiological and pathological conditions. Indeed emerging evidence from over a decade’s research suggests that IL-33 acts as one of the key molecular signalling cues coordinating the network between the immune and CNS systems, particularly during the development of neurological diseases. Here, we highlight the recent advances in our knowledge regarding the distribution and cellular localisation of IL-33 and its receptor ST2 in specific CNS regions, and more importantly the key roles IL-33/ST2 signalling pathway play in CNS function under normal and diseased conditions.",
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AU - Fairlie-Clarke , Karen

AU - Barbour, Mark

AU - Wilson, Chelsey

AU - Hridi, Shehla U.

AU - Allan, Debbie

AU - Jiang, Hui-Rong

PY - 2018/11/20

Y1 - 2018/11/20

N2 - Interleukin-33 (IL-33) is a well-recognised immunomodulatory cytokine which plays critical roles in tissue function and immune-mediated diseases. The abundant expression of IL-33 in brain and spinal cord prompted many scientists to explore its unique role in the central nervous system (CNS) under physiological and pathological conditions. Indeed emerging evidence from over a decade’s research suggests that IL-33 acts as one of the key molecular signalling cues coordinating the network between the immune and CNS systems, particularly during the development of neurological diseases. Here, we highlight the recent advances in our knowledge regarding the distribution and cellular localisation of IL-33 and its receptor ST2 in specific CNS regions, and more importantly the key roles IL-33/ST2 signalling pathway play in CNS function under normal and diseased conditions.

AB - Interleukin-33 (IL-33) is a well-recognised immunomodulatory cytokine which plays critical roles in tissue function and immune-mediated diseases. The abundant expression of IL-33 in brain and spinal cord prompted many scientists to explore its unique role in the central nervous system (CNS) under physiological and pathological conditions. Indeed emerging evidence from over a decade’s research suggests that IL-33 acts as one of the key molecular signalling cues coordinating the network between the immune and CNS systems, particularly during the development of neurological diseases. Here, we highlight the recent advances in our knowledge regarding the distribution and cellular localisation of IL-33 and its receptor ST2 in specific CNS regions, and more importantly the key roles IL-33/ST2 signalling pathway play in CNS function under normal and diseased conditions.

KW - IL-33

KW - ST2

KW - central nervous system

KW - expression

KW - neurological diseases

UR - https://www.frontiersin.org/journals/immunology

U2 - 10.3389/fimmu.2018.02596

DO - 10.3389/fimmu.2018.02596

M3 - Review article

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JO - Frontiers in Immunology

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JF - Frontiers in Immunology

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ER -