Explosivity: an unusual challenge in drug development

N. Westwood; D. Londesbrough; S. J. Ford; G. W. Halbert

Explosivity: an unusual challenge in drug development

N. Westwood, D. Londesbrough, S. J. Ford, G. W. Halbert

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to conference › Poster

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Abstract

There remains an urgent global need for new drugs to combat diseases such as malaria, tuberculosis and cancer, as well as overcoming increasing antibiotic resistance. Chemists are moving into ‘new chemical space’ for drug design (1,2) and with this comes the possibility of traditional (and stable) ‘carbon-carbon’ bond structures being replaced by more ‘exotic’ bonding arrangements. While the implication of this on pharmaceutical stability can often be mitigated by suitable formulation and storage strategies, we came across an unusual case of chemical stability: the possibility that the drug was an explosive! By pushing drug designing into uncharted chemical space it could be argued that the possibility of finding explosive molecules of pharmaceutical interest will increase.

Original language	English
Number of pages	1
Publication status	Published - 4 Apr 2016
Event	10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology - SECC, Glasgow, United Kingdom Duration: 4 Apr 2016 → 7 Apr 2016

Conference

Conference	10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
Country/Territory	United Kingdom
City	Glasgow
Period	4/04/16 → 7/04/16

Keywords

drug development
explosivity testing
drug design

Access to Document

Westwood-etal-PBP-2016-Explosivity-an-unusual-challenge-in-drug-developmentAccepted author manuscript, 1.46 MB

Cencer Research UK (External organisation)
Halbert, G. (Member)
2011 → …
Activity: Membership types › Membership of committee

Cite this

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T1 - Explosivity

T2 - 10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology

AU - Westwood, N.

AU - Londesbrough, D.

AU - Ford, S. J.

AU - Halbert, G. W.

PY - 2016/4/4

Y1 - 2016/4/4

N2 - There remains an urgent global need for new drugs to combat diseases such as malaria, tuberculosis and cancer, as well as overcoming increasing antibiotic resistance. Chemists are moving into ‘new chemical space’ for drug design (1,2) and with this comes the possibility of traditional (and stable) ‘carbon-carbon’ bond structures being replaced by more ‘exotic’ bonding arrangements. While the implication of this on pharmaceutical stability can often be mitigated by suitable formulation and storage strategies, we came across an unusual case of chemical stability: the possibility that the drug was an explosive! By pushing drug designing into uncharted chemical space it could be argued that the possibility of finding explosive molecules of pharmaceutical interest will increase.

AB - There remains an urgent global need for new drugs to combat diseases such as malaria, tuberculosis and cancer, as well as overcoming increasing antibiotic resistance. Chemists are moving into ‘new chemical space’ for drug design (1,2) and with this comes the possibility of traditional (and stable) ‘carbon-carbon’ bond structures being replaced by more ‘exotic’ bonding arrangements. While the implication of this on pharmaceutical stability can often be mitigated by suitable formulation and storage strategies, we came across an unusual case of chemical stability: the possibility that the drug was an explosive! By pushing drug designing into uncharted chemical space it could be argued that the possibility of finding explosive molecules of pharmaceutical interest will increase.

KW - drug development

KW - explosivity testing

KW - drug design

M3 - Poster

Y2 - 4 April 2016 through 7 April 2016

ER -

Explosivity: an unusual challenge in drug development

Abstract

Conference

Keywords

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Activities

Cencer Research UK (External organisation)

Cite this