Explosivity: an unusual challenge in drug development

N. Westwood, D. Londesbrough, S. J. Ford, G. W. Halbert

Research output: Contribution to conferencePoster

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Abstract

There remains an urgent global need for new drugs to combat diseases such as malaria, tuberculosis and cancer, as well as overcoming increasing antibiotic resistance. Chemists are moving into ‘new chemical space’ for drug design (1,2) and with this comes the possibility of traditional (and stable) ‘carbon-carbon’ bond structures being replaced by more ‘exotic’ bonding arrangements. While the implication of this on pharmaceutical stability can often be mitigated by suitable formulation and storage strategies, we came across an unusual case of chemical stability: the possibility that the drug was an explosive! By pushing drug designing into uncharted chemical space it could be argued that the possibility of finding explosive molecules of pharmaceutical interest will increase.
Original languageEnglish
Number of pages1
Publication statusPublished - 4 Apr 2016
Event10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology - SECC, Glasgow, United Kingdom
Duration: 4 Apr 20167 Apr 2016

Conference

Conference10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
CountryUnited Kingdom
CityGlasgow
Period4/04/167/04/16

Keywords

  • drug development
  • explosivity testing
  • drug design

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