Projects per year
Abstract
Pharmaceutical cocrystals use common robust hydrogen bonding synthons to create novel materials with different physicochemical properties. In this systematic study of a series of cocrystals, we explore the effect of high pressure on one of these commonly used motifs, the acid-pyridine motif, to assess the commonality of behaviour under extreme conditions. We have surveyed five pyridine dicarboxylic acid systems using both synchrotron and neutron diffraction methods to elucidate the changes in structure. We observe that the hydrogen bonding in these systems compress at a similar rate despite the changes to the molecular make-up of the solids and that on compression the changes in structure are indicative that the layers move along the major slip planes in the structure. We have observed two phase transitions to new forms of the pyrazine:malonic acid system, one for each stoichiometric ratio. This study demonstrates that the combination of two complementary diffraction approaches is key to understanding polymorphic behaviour at high pressure.
Original language | English |
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Article number | 123514 |
Number of pages | 12 |
Journal | International Journal of Pharmaceutics |
Volume | 647 |
Early online date | 14 Oct 2023 |
DOIs | |
Publication status | Published - 25 Nov 2023 |
Keywords
- high-pressure
- intermolecular interactions
- diffraction
- X-ray
- neutron
- phase transition
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Dive into the research topics of 'Exploring the effects of high pressure on hydrogen bonding in pharmaceutical cocrystals: a systematic study of pyridine dicarboxylic acid systems using synchrotron and neutron diffraction'. Together they form a unique fingerprint.Projects
- 2 Finished
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Investigation of pyrazine:diacid co-crystal systems at high pressure
Oswald, I. (Principal Investigator), Ward, M. (Co-investigator), Bull, C. L. (Co-investigator) & Funnell, N. P. (Co-investigator)
1/10/20 → 6/10/20
Project: Research
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Pressure-Induced Nucleation for the Continuous Manufacture of Supramolecular assemblies
Sefcik, J. (Co-investigator), Ter Horst, J. (Co-investigator) & Oswald, I. (Fellow)
EPSRC (Engineering and Physical Sciences Research Council)
1/06/16 → 30/11/22
Project: Research Fellowship
Datasets
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Data for: "Exploring the Effects of High Pressure on Hydrogen Bonding in Pharmaceutical Cocrystals: A Systematic Study of Pyridine Dicarboxylic Acid Systems Using Synchrotron and Neutron Diffraction"
Ward, M. (Creator), Warren, M. (Creator), Funnell, N. P. (Creator), Bull, C. L. (Creator) & Oswald, I. (Creator), University of Strathclyde, 29 Jun 2023
DOI: 10.15129/5f78c84f-9d85-4d63-ad0e-dbc7f4173ea9, https://data.isis.stfc.ac.uk/doi/study/112432000
Dataset