Exploiting dimerization of purely peptidic amphiphiles to form vesicles

Thomas B. Schuster; Dirk De Bruyn Ouboter; Nico Bruns; Wolfgang Meier

doi:10.1002/smll.201100701

Exploiting dimerization of purely peptidic amphiphiles to form vesicles

Thomas B. Schuster, Dirk De Bruyn Ouboter, Nico Bruns, Wolfgang Meier^*

^*Corresponding author for this work

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Short, amphiphilic peptides self-assemble into vesicles due to dimerization. These additional interactions lead to the formation of stable peptide membranes. The vesicles demonstrate pH responsiveness and the ability to encapsulate hydrophobic and hydrophilic moieties within their structure, and therefore may be used as an advanced, biodegradable, drug-delivery system.

Original language	English
Pages (from-to)	2158-2162
Number of pages	5
Journal	Small
Volume	7
Issue number	15
DOIs	https://doi.org/10.1002/smll.201100701
Publication status	Published - 8 Aug 2011

Keywords

biomaterials
colloids
drug delivery
membranes
self-assembly

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10.1002/smll.201100701

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abstract = "Short, amphiphilic peptides self-assemble into vesicles due to dimerization. These additional interactions lead to the formation of stable peptide membranes. The vesicles demonstrate pH responsiveness and the ability to encapsulate hydrophobic and hydrophilic moieties within their structure, and therefore may be used as an advanced, biodegradable, drug-delivery system.",

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AU - Schuster, Thomas B.

AU - De Bruyn Ouboter, Dirk

AU - Bruns, Nico

AU - Meier, Wolfgang

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AB - Short, amphiphilic peptides self-assemble into vesicles due to dimerization. These additional interactions lead to the formation of stable peptide membranes. The vesicles demonstrate pH responsiveness and the ability to encapsulate hydrophobic and hydrophilic moieties within their structure, and therefore may be used as an advanced, biodegradable, drug-delivery system.

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KW - colloids

KW - drug delivery

KW - membranes

KW - self-assembly

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Exploiting dimerization of purely peptidic amphiphiles to form vesicles

Abstract

Keywords

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